Remoxipride hydrochloride manufacturers
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| | Remoxipride hydrochloride Basic information |
| | Remoxipride hydrochloride Chemical Properties |
| Melting point | 168-169 °C | | storage temp. | Store at RT | | solubility | Chloroform (Sparingly), Water (Slightly, Sonicated) | | form | White solid. | | color | White to Off-White | | Water Solubility | Soluble to 100 mM in water | | Stability: | Hygroscopic |
| | Remoxipride hydrochloride Usage And Synthesis |
| Uses | Specific dopamine D2-receptor antagonist. Antipsychotic. | | Biological Activity | Standard D 2 receptor antagonist showing some selectivity over D 3 and D 4 receptors (K i values are ~ 300, ~ 1600, and ~ 2800 nM for D 2 , D 3 and D 4 receptors respectively). In vivo remoxipride is an antipsychotic which does not cause extrapyramidal side effects and is 50-fold more potent than sulpiride in antagonising the effects of apomorphine in the rat. | | in vivo | (S)-Remoxipride hydrochloride (0.1-100 μM/kg; i.p. 60 min prior to apomorphine) blockades apomorphine-induced behaviors s in rats and vomiting in dogs[1].
(S)-Remoxipride hydrochloride (0.1-10 mg/kg; i.p. 30 min prior to apomorphine) displaces [3H]spiperone from both striatal and extra-striatal areas[1]. |
| | Remoxipride hydrochloride Preparation Products And Raw materials |
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