2-Chloro-3-nitropyridine-6-amine manufacturers
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| | 2-Chloro-3-nitropyridine-6-amine Basic information |
| Product Name: | 2-Chloro-3-nitropyridine-6-amine | | Synonyms: | 2-Chloro-3-nitropyridine-6-amine;6-Amino-2-chloro-3-nitropyridine;6-Chloro-5-nitro-pyridin-2-ylaMine;2-Pyridinamine, 6-chloro-5-nitro-;2-Chloro-3-nitropyridine-6-amine ISO 9001：2015 REACH;2-Amino-6-chloro-5-nitropyridine;6-Chloro-5-nitro-2-pyridinamine;2-Chloro-6-amino-3-nitropyridine | | CAS: | 84487-03-6 | | MF: | C5H4ClN3O2 | | MW: | 173.56 | | EINECS: | | | Product Categories: | | | Mol File: | 84487-03-6.mol |  |
| | 2-Chloro-3-nitropyridine-6-amine Chemical Properties |
| Melting point | 188 °C | | Boiling point | 393.6±37.0 °C(Predicted) | | density | 1.596±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | -1.22±0.37(Predicted) | | Appearance | Yellow to green Solid |
| | 2-Chloro-3-nitropyridine-6-amine Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 2-amino-5-nitro-6-chloropyridine from 2-amino-6-chloropyridine was as follows: concentrated nitric acid (2.39 mL, 35.00 mmol) was slowly added dropwise at 0 °C to a mixture containing concentrated sulfuric acid (56 mL, 1050 mmol) and 6-chloropyridin-2-amine (3.00 g, 23.34 mmol). The reaction mixture was kept stirred at 0 °C for 4 hours. After completion of the reaction, the mixture was carefully poured into ice water. The mixture was extracted with ethyl acetate (3 x 100 mL). The organic layers were combined, dried with anhydrous sodium sulfate and subsequently concentrated. The residue was purified by column chromatography to afford the target product 2-amino-5-nitro-6-chloropyridine (1.38 g, 34% yield). | | References | [1] Patent: WO2018/146472, 2018, A1. Location in patent: Page/Page column 54; 55
[2] Patent: WO2018/146469, 2018, A1. Location in patent: Page/Page column 44-45 |
| | 2-Chloro-3-nitropyridine-6-amine Preparation Products And Raw materials |
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