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| | PROMECARB Basic information |
| | PROMECARB Chemical Properties |
| Melting point | 87.5℃ | | Boiling point | 117℃ (10-12 Torr) | | density | 1.0681 (rough estimate) | | refractive index | 1.5220 (estimate) | | storage temp. | 0-6°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Crystalline | | pka | 12.37±0.46(Predicted) | | color | White to Off-White | | Water Solubility | 92mg/L(room temperature) | | Merck | 13,7875 | | BRN | 2111695 | | Henry's Law Constant | 1.1×102 mol/(m3Pa) at 25℃, Duchowicz et al. (2020) | | InChI | 1S/C12H17NO2/c1-8(2)10-5-9(3)6-11(7-10)15-12(14)13-4/h5-8H,1-4H3,(H,13,14) | | InChIKey | DTAPQAJKAFRNJB-UHFFFAOYSA-N | | SMILES | CNC(=O)Oc1cc(C)cc(c1)C(C)C | | CAS DataBase Reference | 2631-37-0(CAS DataBase Reference) | | EPA Substance Registry System | Promecarb (2631-37-0) |
| Hazard Codes | T,N | | Risk Statements | 25-50/53 | | Safety Statements | 24-37-45-60-61 | | RIDADR | 2757 | | WGK Germany | 3 | | RTECS | FB8050000 | | HazardClass | 6.1(a) | | PackingGroup | II | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 2 Oral
Acute Tox. 3 Dermal
Aquatic Acute 1
Aquatic Chronic 1 | | Hazardous Substances Data | 2631-37-0(Hazardous Substances Data) | | Toxicity | LD50 in mice, rats (mg/kg): 39.5, 60 orally (Miyao) |
| | PROMECARB Usage And Synthesis |
| Chemical Properties | Colorless, crystalline solid.
Insoluble in water; soluble in alcohol. | | Chemical Properties | Promecarb is a colorless, odorless, crystalline
solid | | Uses | Insecticide. | | Uses | Promecarb is a carbamate pesticide. | | Definition | ChEBI: Promecarb is an alkylbenzene. | | Production Methods | Promecarb is synthesised through a straightforward esterification process involving 3-isopropyl-5-methylphenol and methyl isocyanate. The phenol derivative, which serves as the aromatic backbone, is first prepared via alkylation of a methylphenol compound with isopropyl halide under basic conditions. Once the substituted phenol is obtained, it undergoes a nucleophilic reaction with methyl isocyanate, forming the methylcarbamate ester linkage that defines promecarb’s insecticidal activity. This reaction typically occurs in an inert solvent like toluene or acetonitrile, under controlled temperature and pH to ensure selectivity and minimize side reactions. | | General Description | Almost odorless, colorless crystalline solid. Used as a non-systemic contact insecticide. Not for sale or use in the USA. | | Reactivity Profile | PROMECARB is a carbamate ester. Carbamates are chemically similar to, but more reactive than amides. Like amides they form polymers such as polyurethane resins. Carbamates are incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen is produced by the combination of active metals or nitrides with carbamates. Strongly oxidizing acids, peroxides, and hydroperoxides are incompatible with carbamates. | | Hazard | Toxic by ingestion. | | Health Hazard | PROMECARB is highly toxic by ingestion and is absorbed through the intact skin. It is a reversible cholinesterase inhibitor and its effects are related to action on the nervous sysem. | | Fire Hazard | (Non-Specific -- Carbamate Pesticide, Solid, n.o.s.) Container may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases. Hydrolyzed by alkalis. Stable. No changes observed on storage for 140 hours at122F. | | Mechanism of action | Systemic. Rapid knock down with contact and stomach action. Acetylcholinesterase (AchE) inhibitor. | | Potential Exposure | A potential danger to those involved
in the manufacture, formulation or application of this non-
systemic contact insecticide. | | Shipping | UN2811 Toxic solids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required. | | Incompatibilities | Alkalis. | | Waste Disposal | Small quantities: treat with
alkali and then bury. Large quantities: incineration .
In accordance with 40CFR165, follow recommendations
for the disposal of pesticides and pesticide containers.
Must be disposed properly by following package label
directions or by contacting your local or federal environ-
mental control agency, or by contacting your regional
EPA office. | | Pesticide Type | Insecticide; Veterinary substance |
| | PROMECARB Preparation Products And Raw materials |
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