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2-Fluoropalmitic acid manufacturers
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| | 2-Fluoropalmitic acid Basic information |
| Product Name: | 2-Fluoropalmitic acid | | Synonyms: | 2-FLUOROHEXADECANOIC ACID;JGRIJJOLCNCSNX-UHFFFAOYSA-N;Hexadecanoic acid, 2-fluoro-;2-Fluoropalmitic acid | | CAS: | 16518-94-8 | | MF: | C16H31FO2 | | MW: | 274.41 | | EINECS: | | | Product Categories: | | | Mol File: | 16518-94-8.mol |  |
| | 2-Fluoropalmitic acid Chemical Properties |
| Boiling point | 376.1±12.0 °C(Predicted) | | density | 0.936±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | Soluble in DMSO | | form | crystalline solid | | pka | 2.70±0.21(Predicted) | | color | White to off-white |
| | 2-Fluoropalmitic acid Usage And Synthesis |
| Uses | Quinine (sulfate hydrate) (Standard) is the analytical standard of Quinine (sulfate hydrate). This product is intended for research and analytical applications. Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100mV with an IC50 of 169 μM. | | Definition | ChEBI: 2-fluorohexadecanoic acid is a long-chain fatty acid and a fluoro fatty acid. | | Biological Activity | 2-fluoropalmitic acid inhibits sphingosine biosynthesis and long-chain acyl-coa synthetase [1]. the length of the carbon chain of the fatty acid species defines the substrate specificity for the different acyl-coa synthetases (acs).mammalian long-chain acyl-coa synthetases (acsl) activate fatty acids with chain lengths of 12 to 20 carbon atoms. the long-chain acyl-coa synthetase mrna is expressed virtually in heart, liver, and epididymal adipose tissues and, to a much lesser extent, in brain, small intestine, and lung [2].palmitic acid was a selective cytotoxic substance extracted from the marine algal. at concentrations ranging from 12.5 to 50 μg/ml, palmitic acid showed selective cytotoxicity to human leukemic cells, but no cytotoxicity to normal hdf cells. palmitic acid (50 μg/ml) induced apoptosis in the human leukemic cell line molt-4. palmitic acid also showed in vivo antitumor activity in mice [3]. 2-fluoropalmitic acid showed an inhibitory effect on sphingosine biosynthesis and long-chain acyl-coa synthetase with an ic50 value of 0.2 mm [1]. | | references | [1] soltysiak r m, matsuura f, bloomer d, et al. d, l-α-fluoropalmitic acid inhibits sphingosine base formation and accumulates in membrane lipids of cultured mammalian cells[j]. biochimica et biophysica acta (bba)-lipids and lipid metabolism, 1984, 792(2): 214-226.
[2] suzuki h, kawarabayasi y, kondo j, et al. structure and regulation of rat long-chain acyl-coa synthetase[j]. journal of biological chemistry, 1990, 265(15): 8681-8685.
[3] harada h, yamashita u, kurihara h, et al. antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga[j]. anticancer research, 2001, 22(5): 2587-2590. |
| | 2-Fluoropalmitic acid Preparation Products And Raw materials |
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