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RofluMilast related substance

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RofluMilast related substance Basic information
Product Name:RofluMilast related substance
Synonyms:3-(cyclopropylMethoxy)-N-(3,5-dichloropyridin-4-yl)-4-hydroxybenzaMide;Roflumilast Desdifluoromethyl Impurity;N-(3,5-dichloropyridin-4-yl)-4-hydroxybenzaMide;4-O-Des(difluoromethyl) Roflumilast/3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-hydroxybenzamide;Roflumilast-2;3-(CyclopropylMethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-hydroxybenzaMide;4-O-Des(difluoroMethyl) RofluMilast;RofluMilast IMp.B
CAS:475271-62-6
MF:C16H14Cl2N2O3
MW:353.2
EINECS:
Product Categories:
Mol File:475271-62-6.mol
RofluMilast related substance Structure
RofluMilast related substance Chemical Properties
Melting point 179-182°C
Boiling point 448.6±45.0 °C(Predicted)
density 1.489±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
solubility Acetone, Methanol
pka7.40±0.45(Predicted)
form Solid
color White to Pale Yellow
Major Applicationpharmaceutical (small molecule)
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
Hazard ClassificationsEye Irrit. 2
Skin Irrit. 2
STOT SE 3
MSDS Information
RofluMilast related substance Usage And Synthesis
Uses4-O-Des(difluoromethyl) Roflumilast is an impurity in the preparation of Roflumilast (R639700).
RofluMilast related substance Preparation Products And Raw materials
Tag:RofluMilast related substance(475271-62-6) Related Product Information
4-(Difluoromethoxy)-3-(cyclopropylmethoxy)-benzaldehyde 3,5-Dichloro-4-aminopyridine RofluMilast N-Oxide Roflumilast 4-Amino-3,5-dichloropyridine benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy- BenzaMide, 3,4-bis(cyclopropylMethoxy)-N-(3,5-dichloro-4-pyridinyl)- Roflumilast-d3 N-(3-Chloropyridin-4-yl)-3-(cyclopropylMethoxy)-4-(difluoroMethoxy)benzaMide Roflumilast Impurity 14 4-Amino-3,5-dichloropyridine N-oxide 3-Cyclopropylmethoxy-4-difluoromethoxy-benzoic acid N-(3,5-Dichloro-4-pyridinyl)-3,4-bis(difluoroMethoxy)benzaMide RofluMilast related substance Roflumilast 3-(cyclopropylMethoxy)-N-(3-(cyclopropylMethoxy)-4-(difluoroMethoxy)benzoyl)-N-(3,5-dichloropyridin-4-yl)-4-(difluoroMethoxy)benzaMide Roflumilast N-oxide D4 RofluMilast related substance