PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]-

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PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]- Suppliers list
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PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]- Basic information
Product Name:PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]-
Synonyms:PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]-;Lck Inhibitor;6-(2,6-Dimethylphenyl)-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one;6-(2,6-Dimethylphenyl)-2-[[4-(4-methyl-1-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one;TC-S 7003 (Lck Inhibitor);Lck Inhibitor 25;6-(2,6-Dimethylphenyl)-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)benzo[4,5]imidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one
CAS:847950-09-8
MF:C31H30N8O
MW:530.62
EINECS:
Product Categories:
Mol File:847950-09-8.mol
PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]- Structure
PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]- Chemical Properties
Boiling point 809.1±75.0 °C(Predicted)
density 1.36±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form crystalline solid
pka7.87±0.42(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]- Usage And Synthesis
UsesTC-S 7003 is a novel, potent and orally active inhibitor of Lymphocyte Specific Kinase (Lck).
in vivo

Lck inhibitor (0-60 mg/kg; oral once daily; from day 9 to day 17) showed a dose-dependent inhibition of arthritis[1].
Lck inhibitor (5 mg/kg oral) treatment showed Cmax, AUC0-∞, tmax, and F% were 82 ng/mL, 862 ng h/mL, and 17%, respectively[1].

Animal Model:Male Lewis rat (adjuvant-inducedarthritis model) [1]
Dosage:0, 30, and 60 mg/kg
Administration:Po; once daily; from day 9 today 17
Result:Showed a dose-dependent inhibition of arthritis, with an ED50 estimated at 24 mg/kg.
Animal Model:Sprague-Dawley Rats[1]
Dosage:Po (Pharmacokinetic Analysis)
Administration:5 mg/kg
Result:The Cmax, AUC0-∞, tmax and F% were 82 ng/mL, 862 ng h/mL, and 17%, respectively.
storageStore at -20°C
PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]- Preparation Products And Raw materials
Tag:PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]-(847950-09-8) Related Product Information
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