Rhosin (hydrochloride) manufacturers
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| | Rhosin (hydrochloride) Basic information |
| Product Name: | Rhosin (hydrochloride) | | Synonyms: | Rhosin (hydrochloride);Rhosin HCl;(R,E)-2-amino-3-(1H-indol-3-yl)-N'-(quinoxalin-6-ylmethylene)propanehydrazide hydrochloride;D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride;G04 HYDROCHLORIDE;(2R)-2-amino-3-(1H-indol-3-yl)-N'-[(quinoxalin-6-yl)methylidene]propanehydrazide hydrochloride;plasticity,D1-MSN,MCF7,Apoptosis,hyperexcitability,Rhosin hydrochloride,Ras,stress,Rhosin,selective,inhibit,cells,Inhibitor,resiliency;Rhosin hydrochloride, 10 mM in DMSO | | CAS: | 1281870-42-5 | | MF: | C20H18N6O.ClH | | MW: | 394.86 | | EINECS: | | | Product Categories: | | | Mol File: | 1281870-42-5.mol |  |
| | Rhosin (hydrochloride) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 10 mg/ml; DMSO: 5 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): insol | | form | A solid | | color | Light yellow to yellow |
| | Rhosin (hydrochloride) Usage And Synthesis |
| Uses | Rhosin hydrochloride is the hydrochloride salt of rhosin (CAS# 1173671-63-0) which is a D-tryptophan derivative and an inhibitor of Rho GTPases with potential application in reversing chemotherapy resistance in diffuse-type gastric adenocarinoma. | | in vivo | Rhosin (40 mg/kg; i.p.) treatment prevents social avoidance caused by social defeat stress. Rhosin also blocks sucrose preference deficits induced by defeat in C57Bl6/J (Jackson) mice[3].
Rhosin (30 μM; bilateral, intra- Nucleus Accumbens (NAc) infusions) attenuates stress-induced social avoidance. Rhosin blocks stress-induced hyperexcitability in NAc dopamine 1 receptor medium spiny neurons (D1-MSNs). Rhosin prevents decreased excitatory transmission on NAc D1-MSNs. Rhosin enhances spine density in defeat mice[3]. | Animal Model: | D1-GFP or D2-GFP hemizygote mice on a C57BL/6J background[3] | | Dosage: | 40 mg/kg | | Administration: | I.p. | | Result: | Rhosin was systemically administered 15 min prior to defeat to block RhoA activation. While defeat significantly reduced the time that experimental mice spent interacting with a novel mouse, Rhosin administration suppressed this effect without affecting locomotor behaviors. |
| | storage | Store at -20°C |
| | Rhosin (hydrochloride) Preparation Products And Raw materials |
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