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| | Tipifarnib (S enantioMer) Basic information |
| Product Name: | Tipifarnib (S enantioMer) | | Synonyms: | (S)-(-)-R-115777;(S)-(-)-R-115777;IND-58359 S ENANTIOMER;IND-58359 S enantiomer;Tipifarnib (S enantioMer);Tipifarnib (IND-58359) S enantiomer;6-[(S)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one;Tipifarnib S;2(1H)-Quinolinone, 6-[(S)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl- | | CAS: | 192185-71-0 | | MF: | C27H22Cl2N4O | | MW: | 489.4 | | EINECS: | | | Product Categories: | | | Mol File: | 192185-71-0.mol |  |
| | Tipifarnib (S enantioMer) Chemical Properties |
| Boiling point | 681.7±55.0 °C(Predicted) | | density | 1.33±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 10 mg/ml; Methanol: 5 mg/ml | | form | A crystalline solid | | pka | 7.20±0.10(Predicted) | | color | White to light yellow |
| | Tipifarnib (S enantioMer) Usage And Synthesis |
| Uses | Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM. Tipifarnib S enantiomer is the less active isomer. | | Definition | ChEBI: 6-[(S)-amino-(4-chlorophenyl)-(3-methyl-4-imidazolyl)methyl]-4-(3-chlorophenyl)-1-methyl-2-quinolinone is a diarylheptanoid. | | References | [1] Kraus JM, et al. Rational modification of a candidate cancer drug for use against Chagas disease. J Med Chem. 2009 Mar 26;52(6):1639-47. DOI:10.1021/jm801313t |
| | Tipifarnib (S enantioMer) Preparation Products And Raw materials |
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