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| | IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID Basic information |
| | IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID Chemical Properties |
| Melting point | 232-234℃ | | density | 1.41±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | form | Powder | | pka | -4.33±0.41(Predicted) | | color | White to off-white | | InChI | 1S/C8H6N2O2/c11-8(12)6-5-10-4-2-1-3-7(10)9-6/h1-5H,(H,11,12) | | InChIKey | WQLJLPDGSLZYEP-UHFFFAOYSA-N | | SMILES | OC(=O)c1cn2ccccc2n1 | | CAS DataBase Reference | 64951-08-2(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38-36-22 | | Safety Statements | 26-36/37/39-22 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29332900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID Usage And Synthesis |
| Chemical Properties | White to off-white solid | | Synthesis | Step 2: Synthesis of imidazo[1,2-a]pyridine-2-carboxylic acid
Sodium hydroxide (85 mg, 2.1 mmol) was added to a stirred solution of ethyl imidazo[1,2-a]pyridine-2-carboxylate (135 mg, 0.7 mmol) in ethanol/water (1:1, 5.0 mL). The reaction mixture was heated at 60°C for 3 hours. After completion of the reaction, the mixture was concentrated under reduced pressure. Cold water was added, followed by acidification with 10% aqueous hydrochloric acid to pH < 7. The precipitated solid was collected by filtration and dried to afford imidazo[1,2-a]pyridine-2-carboxylic acid (110 mg, 73% yield). | | References | [1] Patent: US2010/160323, 2010, A1. Location in patent: Page/Page column 31
[2] Journal of Medicinal Chemistry, 2003, vol. 46, # 18, p. 3914 - 3929
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 5, p. 1870 - 1873
[4] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 7, p. 1572 - 1575 |
| | IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID Preparation Products And Raw materials |
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