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| | imidazo[1,2-a]pyridine-6-carboxylic acid Basic information |
| Product Name: | imidazo[1,2-a]pyridine-6-carboxylic acid | | Synonyms: | imidazo[2,1-f]pyridine-6-carboxylic acid;Imidazo[1,2-a]pyridine-6-carboxylicacid97%;Imidazole[1,2-a]pyridine-6-carboxylic acid;Imidazo[1,2-a]pyridine-6-...;6-Carboxyimidazo[1,2-a]pyridine;IMidazo[1,2-a]pyridine-6-carboxylic acid hydrochloride;H-iMidazo[1,2-a]pyridin-6-carboxylic acid;iMidazo[1,2-a]pyridin-6-carboxylic acid | | CAS: | 139022-25-6 | | MF: | C8H6N2O2 | | MW: | 162.15 | | EINECS: | | | Product Categories: | Carboxylic Acids;Fused Ring Systems;Building Blocks;Imidazo[x,x-y]pyridine;blocks;Carboxes;Imidazoles;Pyridines;pharmacetical;Carboxylic Acids | | Mol File: | 139022-25-6.mol | ![imidazo[1,2-a]pyridine-6-carboxylic acid Structure](CAS/GIF/139022-25-6.gif) |
| | imidazo[1,2-a]pyridine-6-carboxylic acid Chemical Properties |
| Melting point | 250 | | density | 1.41 | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 0.67±0.41(Predicted) | | form | Solid | | color | Pale Beige to Light Beige | | Stability: | Hygroscopic | | InChI | InChI=1S/C8H6N2O2/c11-8(12)6-1-2-7-9-3-4-10(7)5-6/h1-5H,(H,11,12) | | InChIKey | ONOJJCTXSDBVSP-UHFFFAOYSA-N | | SMILES | C12=NC=CN1C=C(C(O)=O)C=C2 |
| | imidazo[1,2-a]pyridine-6-carboxylic acid Usage And Synthesis |
| Uses | Imidazo[1,2-a]pyridine-6-carboxylic acid is a brown solid that should be stored sealed at room temperature and away from light. It is a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research. | | Synthesis | Step 2. Imidazo[1,2-a]pyridine-6-carboxylic acid hydrochloride (170 g) was dissolved in water (600 mL) and heated until completely dissolved to form a clarified solution. Subsequently, the pH was adjusted to 5-6 by slowly adding 2 M NaOH aqueous solution. the reaction mixture was cooled to 0 °C in an ice-water bath. The precipitate precipitated was collected by vacuum filtration, washed with ethanol and dried under vacuum to afford the target product imidazo[1,2-a]pyridine-6-carboxylic acid (107.2 g, 77% yield) as a light yellow powder. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6) and mass spectrometry (ESI+): 1H NMR δ 13.76-12.82 (br, 1H), 9.28 (s, 1H), 8.10 (s, 1H), 7.68 (s, 1H), 7.64-7.56 (m, 2H); MS (ESI+) m/z: 163 [M + H]+. | | References | [1] Patent: WO2013/127266, 2013, A1. Location in patent: Page/Page column 130
[2] Patent: WO2013/127267, 2013, A1. Location in patent: Page/Page column 81; 82
[3] Patent: WO2013/127268, 2013, A1. Location in patent: Page/Page column 59; 60
[4] Patent: WO2013/130943, 2013, A1. Location in patent: Paragraph 0181 |
| | imidazo[1,2-a]pyridine-6-carboxylic acid Preparation Products And Raw materials |
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