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| | 2-Chloro-2,2-difluoroacetophenone Basic information |
| Product Name: | 2-Chloro-2,2-difluoroacetophenone | | Synonyms: | CHLORODIFLUOROACETOPHENONE;alpha,alpha-Difluorophenacyl chloride;A-CHLORO-A,A-DIFLUOROACETOPHENONE;ALPHA-CHLORO-ALPHA,ALPHA-DIFLUOROACETOPHENONE;ChlorodifluoroMethyl phenyl ketone;2-Chloro-2,2-d;2-chloro-2,2-difluoro-1-phenylethanone;2-chloro-2,2-difluoro-1-phenyl-ethanone | | CAS: | 384-67-8 | | MF: | C8H5ClF2O | | MW: | 190.57 | | EINECS: | 621-031-1 | | Product Categories: | Fluorine series | | Mol File: | 384-67-8.mol |  |
| | 2-Chloro-2,2-difluoroacetophenone Chemical Properties |
| Melting point | 102-103 °C | | Boiling point | 94-96 °C35 mm Hg(lit.) | | density | 1.293 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.497(lit.) | | Fp | 163 °F | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Difficult to mix. | | form | liquid | | color | Clear, colourless | | BRN | 2251448 | | InChI | 1S/C8H5ClF2O/c9-8(10,11)7(12)6-4-2-1-3-5-6/h1-5H | | InChIKey | MNOONJNILVDLSW-UHFFFAOYSA-N | | SMILES | FC(F)(Cl)C(=O)c1ccccc1 | | CAS DataBase Reference | 384-67-8(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37 | | RIDADR | UN 3334 | | WGK Germany | 3 | | F | 19 | | Hazard Note | Irritant | | HS Code | 29147000 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2-Chloro-2,2-difluoroacetophenone Usage And Synthesis |
| Description | Novel and non-ODS-based (ODS = ozone-depleting substance) difluorocarbene reagents for O- and
N-difluoromethylation. PhCOCF2Cl reacts with a variety of structurally diverse phenol derivatives to
produce aryl difluoromethyl ethers in good yields. PhSO2CF2Cl can react with a variety of structurally
diverse phenol derivatives and N-heterocyclic compounds. | | Uses | 2-Chloro-2,2-difluoroacetophenone can be used:
- As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.
- As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.
- As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.
| | General Description | 2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem-difluoromethene derived compounds. | | reaction suitability | reaction type: C-C Bond Formation |
| | 2-Chloro-2,2-difluoroacetophenone Preparation Products And Raw materials |
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