|
|
| | RES-701-1 Basic information |
| Product Name: | RES-701-1 | | Synonyms: | CYCLO(-GLY-ASN-TRP-HIS-GLY-THR-ALA-PRO-BETA-ASP)-TRP-PHE-PHE-ASN-TYR-TYR-TRP;CYCLO(-GLY-ASN-TRP-HIS-GLY-THR-ALA-PRO-BETA-ASP)-TRP-PHE-PHE-ASN-TYR-TYR-TRP-OH;RES-701-1;cyclo(gly-asn-trp-his-gly-thr-ala-pro-*B-asp)-thr;GLY-ASN-TRP-HIS-GLY-THR-ALA-PRO-ASP-TRP-PHE-PHE-ASN-TYR-TYR-TRP;GLY-ASN-TRP-HIS-GLY-THR-ALA-PRO-ASP-TRP-PHE-PHE-ASN-TYR-TYR-TRP-OH;CYCLO(-GLY-ASN-TRP-HIS-GLY-THR-ALA-PRO-ASP)-TRP-PHE-PHE-ASN-TYR-TYR-TRP-OH;L-Tryptophan, glycyl-L-asparaginyl-L-tryptophyl-L-histidylglycyl-L-threonyl-L-alanyl-L-prolyl-L-α-aspartyl-L-tryptophyl-L-phenylalanyl-L-phenylalanyl-L-asparaginyl-L-tyrosyl-L-tyrosyl-, (9→1)-lactam | | CAS: | 151308-34-8 | | MF: | C103H115N23O23 | | MW: | 2043.16 | | EINECS: | | | Product Categories: | | | Mol File: | 151308-34-8.mol |  |
| | RES-701-1 Chemical Properties |
| density | 1.50±0.1 g/cm3(Predicted) | | storage temp. | −20°C | | pka | 3.35±0.10(Predicted) |
| | RES-701-1 Usage And Synthesis |
| Uses | RES-701-1 is a cyclic peptide composed of 16 common L-amino acids, acting as a specific antagonist for the ETB receptor. RES-701-1 can inhibit the binding of 125I-ET-1 (125I-labeled Endothelin (ET)-1) to the ETB receptor, with an IC50 value of 10 nM[1][2]. | | IC 50 | ETB: 10 nM (IC50) | | References | [1] Tanaka T, et al. RES-701-1, a novel, potent, endothelin type B receptor-selective antagonist of microbial origin. Mol Pharmacol. 1994 Apr;45(4):724-30. PMID:8183252
[2] Yamasaki M, et al. RES-701-1, a novel and selective endothelin type B receptor antagonist produced by Streptomyces sp. RE-701 II. Determination of the primary sequence[J]. The Journal of Antibiotics, 1994, 47(3): 276-280. DOI:10.7164/antibiotics.47.276 |
| | RES-701-1 Preparation Products And Raw materials |
|