- Bis-PEG3-acid
-
- $0.00 / 10g
-
2025-06-07
- CAS:96517-92-9
- Min. Order: 10g
- Purity: >98.00%
- Supply Ability: 10g
- Bis-PEG3-acid
-
- $0.00 / 100mg
-
2024-10-24
- CAS:96517-92-9
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| | Bis-PEG4-acid Basic information |
| Product Name: | Bis-PEG4-acid | | Synonyms: | Bis-PEG3-COOH;3,3'-[oxybis(ethane-2,1-diyloxy)]dipropanoic acid;Bis-PEG3-acid;3,3'-((Oxybis(ethane-2,1-diyl))bis(oxy))dipropanoic acid;COOH-PEG2-COOH;4,7,10-trioxa-tridecanedioic acid;HOOCCH2CH2O-PEG2-CH2CH2COOH;Propanoic acid, 3,3'-[oxybis(2,1-ethanediyloxy)]bis- | | CAS: | 96517-92-9 | | MF: | C10H18O7 | | MW: | 250.25 | | EINECS: | | | Product Categories: | | | Mol File: | 96517-92-9.mol |  |
| | Bis-PEG4-acid Chemical Properties |
| Boiling point | 445.4±40.0 °C(Predicted) | | density | 1.239±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | Soluble in Water, DMSO, DMF | | pka | 3.97±0.10(Predicted) | | form | Solid-Liquid Mixture | | color | Colorless to light yellow |
| | Bis-PEG4-acid Usage And Synthesis |
| Description | Bis-PEG3-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | | Uses | Bis-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] Zhao Q, et al. Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J Med Chem. 2019 Oct 24;62(20):9281-9298. DOI:10.1021/acs.jmedchem.9b01264 |
| | Bis-PEG4-acid Preparation Products And Raw materials |
|