- Bis-propargyl-PEG4
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2025-06-07
- CAS:126422-58-0
- Min. Order: 10g
- Purity: >98.00%
- Supply Ability: 10g
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| | Bis-Propargyl-PEG4 Basic information |
| Product Name: | Bis-Propargyl-PEG4 | | Synonyms: | Bis-Propargyl-PEG4;4,7,10,13-Tetraoxahexadeca-1,15-diyne;Alkyne-PEG4-Alkyne;PROPARGYL-PEG4-PROPARGYL;α,ω-bis(O-propargyl)triethylene glycol;Bis-propargyl-PEG3/4,7,10,13-Tetraoxahexadeca-1,15-diyne | | CAS: | 126422-58-0 | | MF: | C12H18O4 | | MW: | 226.27 | | EINECS: | | | Product Categories: | peg | | Mol File: | 126422-58-0.mol |  |
| | Bis-Propargyl-PEG4 Chemical Properties |
| storage temp. | Storage temp. 2-8°C | | form | Liquid | | color | Colorless to light yellow |
| | Bis-Propargyl-PEG4 Usage And Synthesis |
| Description | Bis-propargyl-PEG4 enables Click Chemistry reactions with azide compounds via copper catalyzed azide-alkyne Click Chemistry. The PEG units enhance the solubility of the molecule in aqueous media. | | Uses | Bis-propargyl-PEG3 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG3 is used in the synthesis of zinc-dipicolylamine (ZnDPA) complexes with antiplasmodial activity[1] [2]. Bis-propargyl-PEG3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] Pearlie BURNETTE, et al. Dimeric immuno-modulatory compounds against cereblon-based mechanisms. WO2020014489A2.
[2] Rice DR, et al. Antiplasmodial activity of targeted zinc(II)-dipicolylamine complexes. Bioorg Med Chem. 2017 May 15;25(10):2754-2760. DOI:10.1016/j.bmc.2017.03.050 |
| | Bis-Propargyl-PEG4 Preparation Products And Raw materials |
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