| Company Name: |
T&W GROUP |
| Tel: |
021-61551611 13296011611 |
| Email: |
contact@trustwe.com |
|
| | Cbz-N-amido-PEG3-acid Basic information |
| Product Name: | Cbz-N-amido-PEG3-acid | | Synonyms: | 3-oxo-1-phenyl-2,7,10,13-tetraoxa-4-azahexadecan-16-oic acid;Cbz-N-amido-PEG3-acid;CBZ-NH-PEG3-propionic acid;CBZ-12-amino-4,7,10-trioxadodecanoic acid;CBZ-AEEEP;CBZ-N-AMIDO-PEG3-COOH;CbzNH-PEG3-CH2CH2COOH;Cbz-NH-PEG3-C2-acid | | CAS: | 1310327-18-4 | | MF: | C17H25NO7 | | MW: | 355.38 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1310327-18-4.mol |  |
| | Cbz-N-amido-PEG3-acid Chemical Properties |
| storage temp. | 2-8°C | | form | Liquid | | color | Colorless to light yellow |
| | Cbz-N-amido-PEG3-acid Usage And Synthesis |
| Description | Cbz-N-amido-PEG3-acid is a PEG linker containing a CBZ-protected amino group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The protected amine can be deprotected by acidic conditions. | | Uses | Cbz-NH-PEG3-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Cbz-N-amido-PEG3-acid Preparation Products And Raw materials |
|