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| | Cbz-N-amido-PEG2-acid Basic information |
| Product Name: | Cbz-N-amido-PEG2-acid | | Synonyms: | Cbz-N-amido-PEG2-acid;CBZ-NH-PEG2-propionic acid;CBZ-AEEP;CBZ-NH-PEG2-COOH;Cbz-NH-PEG2-C2-acid;4,7,12-Trioxa-10-azatridecanoic acid, 11-oxo-13-phenyl-;CBZ-NH-PEG2-acid;CbzNH-PEG2-CH2CH2COOH/4,7,12-Trioxa-10-azatridecanoic acid, 11-oxo-13-phenyl- | | CAS: | 1347750-76-8 | | MF: | C15H21NO6 | | MW: | 311.33 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1347750-76-8.mol |  |
| | Cbz-N-amido-PEG2-acid Chemical Properties |
| storage temp. | 2-8°C | | form | Solid | | color | White to off-white |
| | Cbz-N-amido-PEG2-acid Usage And Synthesis |
| Description | Cbz-N-amido-PEG2-acid is a PEG linker containing a CBZ-protected amino group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The protected amine can be deprotected by acidic conditions. | | Uses | Cbz-NH-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Cbz-N-amido-PEG2-acid Preparation Products And Raw materials |
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