|
|
| | N-methyl-N-(t-Boc)-PEG4-acid Basic information |
| Product Name: | N-methyl-N-(t-Boc)-PEG4-acid | | Synonyms: | N-methyl-N-(t-Boc)-PEG4-COOH;N-methyl-N-(t-Boc)-PEG4-acid;N-methyl-N-( Boc)-PEG4-acid;5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 2-methyl-, 1-(1,1-dimethylethyl) ester;Boc-MeN-PEG4-CH2CH2COOH;N-methyl-N-(t-Boc)-PEG-COOH;Boc-MeN-PEG4-CH2CH2COOH/5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 2-methyl-, 1-(1,1-dimethylethyl) ester;2,2,5-Trimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azaicosan-20-oic acid | | CAS: | 1260431-01-3 | | MF: | C17H33NO8 | | MW: | 379.45 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1260431-01-3.mol |  |
| | N-methyl-N-(t-Boc)-PEG4-acid Chemical Properties |
| | N-methyl-N-(t-Boc)-PEG4-acid Usage And Synthesis |
| Description | N-methyl-N-(t-Boc)-PEG4-acid is a PEG linker containing a t-Boc protecting group and a terminal carboxylic acid. The t-Boc protecting group is acid lablie. The terminal carboxylic acid can react with primary amines in the presence of activators such as EDC and HATU to form stable amide bonds. The hydrophilic PEG linkers increase the water solubility of the compound in aqueous media. | | Uses | N-Methyl-N-(t-Boc)-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-methyl-N-(t-Boc)-PEG4-acid Preparation Products And Raw materials |
|