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| | FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID Basic information |
| Product Name: | FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID | | Synonyms: | FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID;FMoc-15-aMino-4,7,10,13-tetraoxapentadecacanoic acid;FMoc-NH-PEG4-CH2CH2COOH;3-[2-[2-[2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]propionic acid;5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid 1-(9H-fluoren-9-ylmethyl) ester;3-[2-[2-[2-[2-(9H-fluoren-9-ylMethoxycarbonylaMino)ethoxy]ethoxy]ethoxy]ethoxy]propanoicacid;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azanonadecan-19-oic acid;FmocNH-PEG5-acid | | CAS: | 557756-85-1 | | MF: | C26H33NO8 | | MW: | 487.54 | | EINECS: | 1592732-453-0 | | Product Categories: | peg | | Mol File: | 557756-85-1.mol |  |
| | FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID Chemical Properties |
| Boiling point | 682.1±55.0 °C(Predicted) | | density | 1.219 | | storage temp. | -20°C | | solubility | Soluble in DMSO, DCM, DMF | | form | solid or viscous liquid | | pka | 4.28±0.10(Predicted) | | color | Colorless to light yellow | | Major Application | peptide synthesis | | InChI | InChI=1S/C26H33NO8/c28-25(29)9-11-31-13-15-33-17-18-34-16-14-32-12-10-27-26(30)35-19-24-22-7-3-1-5-20(22)21-6-2-4-8-23(21)24/h1-8,24H,9-19H2,(H,27,30)(H,28,29) | | InChIKey | NUHRPLKTAAVHCZ-UHFFFAOYSA-N | | SMILES | C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)(=O)NCCOCCOCCOCCOCCC(O)=O |
| Safety Statements | 24/25 | | WGK Germany | WGK 2 | | HS Code | 29225090 | | Storage Class | 11 - Combustible Solids |
| | FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID Usage And Synthesis |
| Description | Fmoc-N-amido-PEG4-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | | Chemical Properties | Yellow oil | | Uses | Fmoc-NH-PEG4-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG4-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | reaction suitability | reaction type: Pegylations
reagent type: cross-linking reagent | | IC 50 | Cleavable Linker; PEGs | | References | [1] Cai P, et al. Synthesis of C3-Alkylated Indoles on DNA via Indolyl Alcohol Formation Followed by Metal-FreeTransfer Hydrogenation. Org Lett. 2019 Aug 14. DOI:10.1021/acs.orglett.9b02132 |
| | FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID Preparation Products And Raw materials |
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