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| | Z-15-aMino-4,7,10,13-tetraoxapentadecacanoic acid Basic information |
| Product Name: | Z-15-aMino-4,7,10,13-tetraoxapentadecacanoic acid | | Synonyms: | Z-15-aMino-4,7,10,13-tetraoxapentadecacanoic acid;Z-NH-PEG4-CH2CH2COOH;CBZ-15-aMino-4,7,10,13-tetraoxapentadecacanoic acid;CBZ-NH-PEG4-CH2CH2COOH;CBZ-NH-PEG4-CH2CH2COOH;5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid 1-(phenylmethyl) ester;Cbz-N-amido-PEG4-acid;CBZ-NH-PEG4-propionic acid | | CAS: | 756526-00-8 | | MF: | C19H29NO8 | | MW: | 399.44 | | EINECS: | | | Product Categories: | peg | | Mol File: | 756526-00-8.mol |  |
| | Z-15-aMino-4,7,10,13-tetraoxapentadecacanoic acid Chemical Properties |
| Boiling point | 571.2±50.0 °C(Predicted) | | density | 1.188±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 4.28±0.10(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| | Z-15-aMino-4,7,10,13-tetraoxapentadecacanoic acid Usage And Synthesis |
| Description | Cbz-N-amido-PEG4-acid is a PEG linker containing a CBZ-protected amino group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The protected amine can be deprotected by acidic conditions. | | Uses | Cbz-NH-PEG4-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Z-15-aMino-4,7,10,13-tetraoxapentadecacanoic acid Preparation Products And Raw materials |
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