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| | Propargyl-PEG2- acrylate Basic information |
| Product Name: | Propargyl-PEG2- acrylate | | Synonyms: | Propargyl-PEG2- acrylate;Alkyne-PEG2-AC;PROPARGYL-PEG2-AC;Propargyl-PEG1-acrylate;2-Propenoic acid, 2-(2-propyn-1-yloxy)ethyl ester;Acrylate-PEG1-Propargyl;2-(Prop-2-yn-1-yloxy)ethyl acrylate;2-(Prop-2-yn-1-yloxy)ethyl acrylate , Propargyl-PEG1-acrylate | | CAS: | 52436-42-7 | | MF: | C8H10O3 | | MW: | 154.16 | | EINECS: | | | Product Categories: | peg | | Mol File: | 52436-42-7.mol |  |
| | Propargyl-PEG2- acrylate Chemical Properties |
| | Propargyl-PEG2- acrylate Usage And Synthesis |
| Uses | Propargyl-PEG1-acrylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG1-acrylate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | Biological Activity | Propargyl-PEG1-acrylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | Propargyl-PEG2- acrylate Preparation Products And Raw materials |
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