| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
HJC0197 manufacturers
- HJC0197
-
- $49.00
-
2026-07-27
- CAS:1383539-73-8
- Purity: 99.76%
- Supply Ability: 10g
|
| | HJC0197 Basic information |
| Product Name: | HJC0197 | | Synonyms: | HJC 0197
(HJC0197);HJC0197;5-Pyrimidinecarbonitrile, 4-cyclopentyl-2-[[(2,5-dimethylphenyl)methyl]thio]-1,6-dihydro-6-oxo-;HJC0197,cAMP-signaling,activation,GEF,cellular,Ras,inhibit,HJC-0197,HJC 0197,phosphorylation,processes,Inhibitor;6-Cyclopentyl-2-((2,5-dimethylbenzyl)thio)-4-oxo-1,4-dihydropyrimidine-5-carbonitrile;HJC0197, 10 mM in DMSO | | CAS: | 1383539-73-8 | | MF: | C19H21N3OS | | MW: | 339.45 | | EINECS: | | | Product Categories: | | | Mol File: | 1383539-73-8.mol |  |
| | HJC0197 Chemical Properties |
| solubility | DMF: 10 mg/ml; DMF:PBS(pH7.2) (1:2): 0.2 mg/ml; DMSO: 5 mg/ml | | form | A crystalline solid | | color | White to off-white |
| | HJC0197 Usage And Synthesis |
| Description | Exchange protein activated by cAMP (Epac) proteins mediate cAMP signaling independent of protein kinase A (PKA). HJC0197 is a cell-permeable inhibitor of Epac1 and Epac2 (IC50 = 5.9 μM for Epac2). It inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM, but has no effect on cAMP-induced type I and II PKA activity at this concentration. Pretreatment of HEK293 cells expressing either Epac1 or Epac2 with 10 μM HJC0197 completely blocks Epac-mediated phosphorylation of Akt. HJC0197 has been used to study the role of Epac signaling in chondrogenesis in chicken micromass cultures. | | Uses | HJC0197 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP[1]. | | References | [1] Chen H, et al. 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4038-43. DOI:10.1016/j.bmcl.2012.04.082 |
| | HJC0197 Preparation Products And Raw materials |
|