|
|
| | 6-Maleimidocaproic acid-PFP ester Basic information |
| Product Name: | 6-Maleimidocaproic acid-PFP ester | | Synonyms: | 6-Maleimidocaproic acid-PFP ester;1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, pentafluorophenylester;1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, 2,3,4,5,6-pentafluorophenyl ester;6-maleimidohexanoic acid pentafluorophenyl ester;2,5-dihydro-2,5-dioxy-1H-pyridine-1-hexanoic acidpentafluorobenzenester;Perfluorophenyl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate | | CAS: | 692739-25-6 | | MF: | C16H12F5NO4 | | MW: | 377.26 | | EINECS: | | | Product Categories: | | | Mol File: | 692739-25-6.mol |  |
| | 6-Maleimidocaproic acid-PFP ester Chemical Properties |
| storage temp. | Storage temp. 2-8°C | | form | Solid | | color | White to off-white |
| | 6-Maleimidocaproic acid-PFP ester Usage And Synthesis |
| Description | 6-Maleimidocaproic acid PFP ester contains a maleimide and PFP ester end group. Maleimides react with thiol groups within the pH range of 6.5 to 7.5 and form stable thioester bonds. PFP is an activated ester which can react with amine groups to form stable amide bonds. | | Uses | 6-Maleimidocaproic acid-PFP ester is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | Alkyl-Chain | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | 6-Maleimidocaproic acid-PFP ester Preparation Products And Raw materials |
|