- Mal-PEG5-PFP ester
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2025-06-07
- CAS:1807512-46-4
- Min. Order: 250mg
- Purity: >98.00%
- Supply Ability: 250mg
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| | Mal-PEG5-PFP Basic information |
| Product Name: | Mal-PEG5-PFP | | Synonyms: | Mal-PEG5-PFP;4,7,10,13,16-Pentaoxaoctadecanoic acid, 18-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 2,3,4,5,6-pentafluorophenyl ester;perfluorophenyl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12,15-pentaoxaoctadecan-18-oate;Mal-PEG5-OPFP;Cyclic Peptide Amide Bond Cyclizer | | CAS: | 1807512-46-4 | | MF: | C23H26F5NO9 | | MW: | 555.45 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1807512-46-4.mol |  |
| | Mal-PEG5-PFP Chemical Properties |
| Boiling point | 594.2±50.0 °C(Predicted) | | density | 1.376±0.06 g/cm3(Predicted) | | pka | -2.34±0.20(Predicted) |
| | Mal-PEG5-PFP Usage And Synthesis |
| Description | Mal-PEG5-PFP is a PEG linker containing maleimide and PFP moieties. Maleimides are thiol-reactive and react between pH 6.5 and 7.5 to form thiolester bonds. PFP moieties are amine-reactive and are less susceptible to undergo hydrolysis. The hydrophilic PEG linker increases the water solubility of a compound in aqueous media. | | Uses | Mal-PEG5-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Mal-PEG5-PFP Preparation Products And Raw materials |
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