| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
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| Tel: |
021-61312847; 18021002903 |
| Email: |
3008007409@qq.com |
| Products Intro: |
Product Name:VU0134992 Hcl
CAS:1052515-91-9
Purity:98% Package:2mg Remarks:S23282
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VU0134992(hydrochloride) manufacturers
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| | VU0134992(hydrochloride) Basic information |
| Product Name: | VU0134992(hydrochloride) | | Synonyms: | VU0134992(hydrochloride);VU0134992,oral,hypertension,patch-clamp,electrophysiology,Kir4.1,VU 0134992,Inhibitor,natriuresis,inhibit,VU-0134992 hydrochloride,whole-cell,selective,kaliuresis,VU0134992 hydrochloride,Potassium Channel,KcsA,VU-0134992,diuresis;2-(2-Bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide hydrochloride;VU0134992 hydrochloride, 10 mM in DMSO;VU0134992 Hcl | | CAS: | 1052515-91-9 | | MF: | C20H32BrClN2O2 | | MW: | 447.84 | | EINECS: | | | Product Categories: | | | Mol File: | 1052515-91-9.mol |  |
| | VU0134992(hydrochloride) Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | DMSO: 2mg/mL, clear | | form | Solid | | color | White to off-white |
| | VU0134992(hydrochloride) Usage And Synthesis |
| Uses | VU0134992 hydrochloride is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 μM. VU0134992 hydrochloride is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 μM) at -120 mV[1]. | | Biological Activity | VU0134992 is an orally available, potent and selective modulator of the inward rectifier potassium (Kir) channel Kir4.1 (KCNJ10) th at induces diuresis, natriuresis, and kaliuresis in rats. | | in vivo | VU0134992 hydrochloride (50-100 mg/kg; oral gavage) statistically significantly increased urinary Na+ as well as K+ excretion[1]. | Animal Model: | Male Sprague-Dawley rats (250-300 g)[1] | | Dosage: | Oral gavage | | Administration: | 50 and 100 mg/kg | | Result: | Statistically significantly increased urinary Na+ as well as K+ excretion.
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| | References | [1] Kharade SV, et al. Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992. Mol Pharmacol. 2018 Aug;94(2):926-937. DOI:10.1124/mol.118.112359 |
| | VU0134992(hydrochloride) Preparation Products And Raw materials |
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