[(2R,5R)-5-[(5-FLUOROPYRIDIN-2-YL)OXYMETHYL]-2-METHYLPIPERIDIN-1-YL]-(5-FLUORO-2-PYRIMIDIN-2-YLPHENYL)METHANONE
| 中文名称 | [(2R,5R)-5-[(5-FLUOROPYRIDIN-2-YL)OXYMETHYL]-2-METHYLPIPERIDIN-1-YL]-(5-FLUORO-2-PYRIMIDIN-2-YLPHENYL)METHANONE |
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| 中文同义词 | 化合物DORA-22;化合物DORA-22,10 MM DMSO 溶液;DORA-22试剂;DORA-22试剂 |
| 英文名称 | DORA-22 |
| 英文同义词 | DORA-22;[(2R,5R)-5-[(5-FLUOROPYRIDIN-2-YL)OXYMETHYL]-2-METHYLPIPERIDIN-1-YL]-(5-FLUORO-2-PYRIMIDIN-2-YLPHENYL)METHANONE;DORA 22,DORA22;Methanone, [(2R,5R)-5-[[(5-fluoro-2-pyridinyl)oxy]methyl]-2-methyl-1-piperidinyl][5-fluoro-2-(2-pyrimidinyl)phenyl]-;DORA-22, 10 mM in DMSO |
| CAS号 | 1088991-95-0 |
| 分子式 | C23H22F2N4O2 |
| 分子量 | 424.44 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1088991-95-0.mol |
| 结构式 | ![[(2R,5R)-5-[(5-FLUOROPYRIDIN-2-YL)OXYMETHYL]-2-METHYLPIPERIDIN-1-YL]-(5-FLUORO-2-PYRIMIDIN-2-YLPHENYL)METHANONE 结构式](CAS/20180808/GIF/1088991-95-0.gif) |
[(2R,5R)-5-[(5-FLUOROPYRIDIN-2-YL)OXYMETHYL]-2-METHYLPIPERIDIN-1-YL]-(5-FLUORO-2-PYRIMIDIN-2-YLPHENYL)METHANONE 性质
| 沸点 | 524.3±50.0 °C(Predicted) |
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| 密度 | 1.258±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 1.54±0.22(Predicted) |
[(2R,5R)-5-[(5-FLUOROPYRIDIN-2-YL)OXYMETHYL]-2-METHYLPIPERIDIN-1-YL]-(5-FLUORO-2-PYRIMIDIN-2-YLPHENYL)METHANONE 用途与合成方法
DORA-22 是一种具有口服活性的双 orexinergic receptor 拮抗剂，可改善睡眠中断和记忆障碍。DORA-22 可用于失眠的研究。