N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl)

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N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) Basic information
Product Name:N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl)
Synonyms:N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl);Ethanamine, 2-[2-[2-(aminooxy)ethoxy]ethoxy]-N,N-bis[2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]ethyl]-
CAS:2112737-71-8
MF:C24H44N2O9
MW:504.61
EINECS:
Product Categories:
Mol File:2112737-71-8.mol
N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) Structure
N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) Chemical Properties
storage temp. 2-8°C, protect from light
form Liquid
color Light yellow to yellow
Safety Information
MSDS Information
N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) Usage And Synthesis
DescriptionN-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) consists of two terminal propargyl groups and an aminooxy group. The propargyl groups reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. The aminooxy group is reactive towards aldehydes to form oxime bonds. If a reductant is used, it will form a hydroxylamine linkage. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.
UsesN-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50PEGs
References[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) Preparation Products And Raw materials
Tag:N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl)(2112737-71-8) Related Product Information
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