| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:Mitoquinone
CAS:444890-41-9
Remarks:Reach out to us for more information about custom solutions.
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| Company Name: |
Suzhou yacoo science co.,Ltd
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| Tel: |
0512-87182056 18013166090 |
| Email: |
lingling.qi@yacoo.com.cn |
| Products Intro: |
Product Name:Mitoquinone mesylate
CAS:444890-41-9
Purity:98% Package:10g;50g;1kg;5Kg;25kg;
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| Company Name: |
ShangHai Biochempartner Co.,Ltd
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| Tel: |
177-54423994 17754423994 |
| Email: |
2853530910@QQ.com |
| Products Intro: |
Product Name:Mitoquinone
CAS:444890-41-9
Purity:98% HPLC LCMS Package:100MG;1G
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| Product Name: | MITOQ | | Synonyms: | Mitoquinone | Mitochondria-targeted antioxidant;Mitoquinol(MITOQ);Mitoquinone
Discontinued;Mitoquinone (Mito-Q;MitoQ10 | | CAS: | 444890-41-9 | | MF: | C37H44O4P+ | | MW: | 583.73 | | EINECS: | | | Product Categories: | | | Mol File: | 444890-41-9.mol |  |
| | MITOQ Chemical Properties |
| storage temp. | -20° | | solubility | Soluble in DMSO (70 mg/mL); ethanol (30 mg/mL) | | form | waxy solid | | color | Brown | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| | MITOQ Usage And Synthesis |
| Description | Mitoquinone (444890-40-9) is a mitochondria-targeted antioxidant. Displays cardio- and neuroprotective effects.1Displays beneficial effects in mouse models of Alzheimer’s disease.2Mitoquinone protects pancreatic β-cells against oxidative stress and improves insulin secretion.3 Cell permeable. Mesylate salt (Cat# 10-3914)and mesylate cyclodextrin complex (Cat# 10-3915) are also available. | | Uses | Mitoquinone is a mitochondria-targeted antioxidant. | | References | [1] ANAMITRA GHOSH . Neuroprotection by a mitochondria-targeted drug in a Parkinson’s disease model[J]. Free Radical Biology and Medicine, 2010, 49 11: Pages 1674-1684. DOI:10.1016/j.freeradbiomed.2010.08.028
[2] MEAGAN J MCMANUS J L F Michael P Murphy. The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease.[J]. Journal of Neuroscience, 2011, 31 44: 15703-15715. DOI:10.1523/jneurosci.0552-11.2011
[3] SANGBIN LIM. Mitochondria-targeted antioxidants protect pancreatic β-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity.[J]. Cellular Physiology and Biochemistry, 2011, 28 5: 873-886. DOI:10.1159/000335802
[4] JULIE DEMERS-LAMARCHE. Loss of Mitochondrial Function Impairs Lysosomes.[J]. Nuclear Fusion, 2016, 55 1: 10263-10276. DOI:10.1074/jbc.m115.695825
[5] JIAN ZHOU. Mitochondrial-targeted antioxidant MitoQ provides neuroprotection and reduces neuronal apoptosis in experimental traumatic brain injury possibly via the Nrf2-ARE pathway.[J]. American journal of translational research, 2018, 10 6: 1887-1899.
[6] LI XIAO . The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1[J]. Redox Biology, 2017, 11: Pages 297-311. DOI:10.1016/j.redox.2016.12.022
[7] DENG F, SHARMA I, DAI Y, et al. Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule.[J]. The Journal of clinical investigation, 2019, 42 1: 0. DOI:10.1172/jci129903 |
| | MITOQ Preparation Products And Raw materials |
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