DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE manufacturers
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| | DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Basic information |
| Product Name: | DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE | | Synonyms: | DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE;DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYLPYRIDINE-3,5-DICARBOXYLATE;1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER;3,5-DICARBETHOXY-1,4-DIHYDRO-2,4,6-TRIMETHYLPYRIDINE;3,5-DIETHOXYCARBONYL-1,4-DIHYDRO-2,4,6-COLLIDINE;5-pyridinedicarboxylicacid,1,4-dihydro-2,4,6-trimethyl-diethylester;Dicarbethoxydihydrocollidine;diethyl dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate | | CAS: | 632-93-9 | | MF: | C14H21NO4 | | MW: | 267.32 | | EINECS: | 211-188-0 | | Product Categories: | | | Mol File: | 632-93-9.mol |  |
| | DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Chemical Properties |
| Melting point | 130-132 °C(lit.) | | Boiling point | 410.51°C (rough estimate) | | density | 1.1116 (rough estimate) | | refractive index | 1.5280 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | DMF: 30 mg/ml; DMF:PBS (pH 7.2); (1:7): 0.125 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml | | pka | 3.53±0.70(Predicted) | | form | powder to crystal | | color | White to Orange to Green | | InChI | InChI=1S/C14H21NO4/c1-6-18-13(16)11-8(3)12(14(17)19-7-2)10(5)15-9(11)4/h8,15H,6-7H2,1-5H3 | | InChIKey | CDVAIHNNWWJFJW-UHFFFAOYSA-N | | SMILES | C1(C)NC(C)=C(C(OCC)=O)C(C)C=1C(OCC)=O | | CAS DataBase Reference | 632-93-9(CAS DataBase Reference) | | EPA Substance Registry System | 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, diethyl ester (632-93-9) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39 | | WGK Germany | 3 | | RTECS | US7979375 | | TSCA | TSCA listed | | HS Code | 2933.39.9200 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Usage And Synthesis |
| Description | Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (DDC) inhibits heme production by inhibiting ferrochelatase, the enzyme that catalyzes the addition of Fe2+ to protoporphyrin IX to create heme B. Chronic DDC administration induces Mallory-Denk body formation, a feature of alcoholic and non-alcoholic hepatitis, and reduces IL-12A methylation in mouse liver. | | Chemical Properties | almost white crystalline powder | | Uses | Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate was used to induce Mallory-Denk body formation in mice in vivo. | | Definition | ChEBI: A dihydropyridine that is 2,4,6-trimethyl-1,4-dihydropyridine substituted by ethoxycarbonyl groups at positions 3 and 5. | | Biochem/physiol Actions | Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate blocks the heme synthesis and prevents the induction of hepatic heme oxygenase-1 in mice. | | Purification Methods | Crystallise the ester from hot EtOH/water mixture. [Beilstein 22 H 147, 22 I 529, 22 II 100, 22 III/IV 1594.] | | References | [1] J. ONISAWA R L. Effects of diethyl-1, 4-dihydro-2, 4,6-trimethylpyridine-3,5-dicarboxylate on the metabolism of porphyrins and iron.[J]. The Journal of Biological Chemistry, 1963, 44 1: 724-727. DOI: 10.1016/s0021-9258(18)81326-6
[2] QX YUAN. Mallory body induction in drug-primed mouse liver[J]. Hepatology, 1996, 24 3: Pages 603-612. DOI: 10.1053/jhep.1996.v24.pm0008781332
[3] J. OLIVA S. W F. Changes in IL12A methylation pattern in livers from mice fed DDC[J]. Experimental and molecular pathology, 2012, 92 2: Pages 191-193. DOI: 10.1016/j.yexmp.2012.01.001 |
| | DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Preparation Products And Raw materials |
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