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| | 3-Chloro-5-fluoroaniline Basic information |
| Product Name: | 3-Chloro-5-fluoroaniline | | Synonyms: | BUTTPARK 44\01-96;3-Chloro-5-fluoroaniline98%;3-fluoro-5-chloroaniline;3-Chloro-5-fluoroaniline,97%;1-Amino-3-chloro-5-fluorobenzene;3-Chloro-5-fluoroaniline, 97% 1GR;3-Chloro-5-fluoroaniline, 97% 5GR;3-Chloro-5-fluoroaniline > | | CAS: | 4863-91-6 | | MF: | C6H5ClFN | | MW: | 145.56 | | EINECS: | | | Product Categories: | Fluorine series | | Mol File: | 4863-91-6.mol |  |
| | 3-Chloro-5-fluoroaniline Chemical Properties |
| Boiling point | 98C/19Torr | | density | 1.45 | | refractive index | 1.561-1.563 | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | Liquid | | pka | 2.52±0.10(Predicted) | | color | Clear light yellow to orange | | InChI | 1S/C6H5ClFN/c7-4-1-5(8)3-6(9)2-4/h1-3H,9H2 | | InChIKey | LPIFAHAICWJMRR-UHFFFAOYSA-N | | SMILES | Nc1cc(F)cc(Cl)c1 | | CAS DataBase Reference | 4863-91-6(CAS DataBase Reference) |
| Hazard Codes | Xn,T | | Risk Statements | 36/37/38-20/21/22-23/24/25-22 | | Safety Statements | 36/37/39-26-45 | | RIDADR | 2810 | | WGK Germany | WGK 3 | | Hazard Note | Toxic | | HazardClass | 6.1 | | HS Code | 29214200 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
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| | 3-Chloro-5-fluoroaniline Usage And Synthesis |
| Chemical Properties | Clear orange liquid | | Uses | 3-Chloro-5-fluoroaniline is an aniline derivative with chlorine and fluorine substituents at positions 3 and 5, respectively, which can be used as a reagent for chemical reactions, as a raw material for organic synthesis, and as a component of pharmaceutical intermediates. It is widely used in the synthesis of active pharmaceutical ingredients (APIs), especially antiviral compounds against the influenza A (H1N1) virus. It is also used in the synthesis of glucocorticoid receptor agonists for the treatment of inflammation. In addition, the presence of chloro and fluorine substituents in 3-chloro-5-fluoroaniline allows for further functionalisation such as palladium-catalysed carbon-carbon coupling and nucleophilic aromatic substitution. |
| | 3-Chloro-5-fluoroaniline Preparation Products And Raw materials |
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