DIMAPRIT DIHYDROCHLORIDE manufacturers
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| | DIMAPRIT DIHYDROCHLORIDE Basic information |
| Product Name: | DIMAPRIT DIHYDROCHLORIDE | | Synonyms: | DIMAPRIT 2HCL;DIMAPRIT DIHYDROCHLORIDE;S-(3-DIMETHYLAMINOPROPYL)ISOTHIOUREA 2HCL;S-(3-DIMETHYLAMINOPROPYL)ISOTHIOUREA DIHYDROCHLORIDE;2-(3-(dimethylamino)propyl)-2-thio-pseudouredihydrochloride;2-(3’-dimethylaminopropylthio)pseudoureadihydrochloride;2-(3-dimethylaminopropyl)-2-thiopseudoureadihydrochloride;[3-(carbamimidoylsulfanyl)propyl]dimethylamine dihydrochloride | | CAS: | 23256-33-9 | | MF: | C6H16ClN3S | | MW: | 197.73 | | EINECS: | | | Product Categories: | Histamine receptor | | Mol File: | 23256-33-9.mol |  |
| | DIMAPRIT DIHYDROCHLORIDE Chemical Properties |
| storage temp. | Desiccate at RT | | solubility | H2O: ≥50mg/mL | | form | powder | | color | white to off-white | | Water Solubility | Soluble to 100 mM in water | | InChI | 1S/C6H15N3S.2ClH/c1-9(2)4-3-5-10-6(7)8;;/h3-5H2,1-2H3,(H3,7,8);2*1H | | InChIKey | DFWCPLGXFMSUCW-UHFFFAOYSA-N | | SMILES | Cl.Cl.CN(C)CCCSC(N)=N |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | DIMAPRIT DIHYDROCHLORIDE Usage And Synthesis |
| Uses | Histamine H2 receptor agonist | | Biological Activity | Selective H 2 agonist with central effects upon systemic administration. Also inhibits nNOS (IC 50 = 49 μ M). | | in vivo | Dimaprit stimulates gastric acid secretion in rats (1.25 μM/kg/min; rapid i.v. injection), cats (2-64 μM/h; i.v.) and dogs (1-100 nM/kg/min; i.v.)[1].
Dimaprit (0.01-1 μM/kg; i.v. at intervals of 5 min) causes dose-dependent falls in blood pressure in cats. Dimaprit (1-100 nM; intra-arterial injection) causes vasodilatation in the femoral vascular bed, and it (1 μM/kg; bolus or intravenous injection) has no effect on heart rate[1]. | | IC 50 | H2 Receptor; nNOS: 49 μM (IC50) | | storage | Room temperature (desiccate) |
| | DIMAPRIT DIHYDROCHLORIDE Preparation Products And Raw materials |
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