- 2,4-Difluoroaniline
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- $0.00 / 25KG
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2026-01-30
- CAS:367-25-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
- 2,4-Difluoroaniline
-
- $0.00 / 25kg
-
2025-12-01
- CAS:367-25-9
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10000KGS
- 2,4-Difluoroaniline
-
- $9.00 / 1KG
-
2025-09-25
- CAS:367-25-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| Product Name: | 2,4-Difluoroaniline | | Synonyms: | 2,4-difluoro-anilin;Aniline, 2,4-difluoro-;Benzenamine, 2,4-difluoro-;LABOTEST-BB LTBB000653;AKOS 91127;2,4-DIFLUOROPHENYLAMINE;2,4-DIFLUOROBENZENAMINE;1-amino-2,4-difluorobenzene | | CAS: | 367-25-9 | | MF: | C6H5F2N | | MW: | 129.11 | | EINECS: | 206-687-5 | | Product Categories: | Fluorine series;Amines;C2 to C6;Nitrogen Compounds;Fluorobenzene Series;pharmacetical;Aniline;Fluorobenzene;Anilines, Aromatic Amines and Nitro Compounds;bc0001 | | Mol File: | 367-25-9.mol |  |
| | 2,4-Difluoroaniline Chemical Properties |
| Melting point | -7.5 °C (lit.) | | Boiling point | 170 °C/753 mmHg (lit.) | | density | 1.268 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.506(lit.) | | Fp | 145 °F | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | Not miscible or difficult to mix. | | form | Liquid | | pka | 3.26±0.10(Predicted) | | color | Clear brown | | Specific Gravity | 1.284 (20/4℃) | | Water Solubility | 1-5 g/100 mL at 20.55 ºC | | Merck | 14,3147 | | BRN | 2802556 | | Stability: | Stable. Combustible. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides. | | InChI | 1S/C6H5F2N/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2 | | InChIKey | CEPCPXLLFXPZGW-UHFFFAOYSA-N | | SMILES | Nc1ccc(F)cc1F | | LogP | 1.7 at 25℃ and pH5-9 | | CAS DataBase Reference | 367-25-9(CAS DataBase Reference) | | NIST Chemistry Reference | 2,4-Difluoroaniline(367-25-9) | | EPA Substance Registry System | 2,4-Difluoroaniline (367-25-9) |
| Hazard Codes | Xn,T,Xi | | Risk Statements | 20/21/22-36/37/38 | | Safety Statements | 28-36/37/39-26-36 | | RIDADR | UN 2941 6.1/PG 3 | | WGK Germany | 1 | | RTECS | BX3680000 | | F | 8-9-23 | | Hazard Note | Toxic | | TSCA | TSCA listed | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29214210 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Dermal
Acute Tox. 4 Oral |
| | 2,4-Difluoroaniline Usage And Synthesis |
| Description | 2,4-difluoroaniline is an important intermediate used in organic synthesis, pharmaceuticals agrochemicals, dyes, and agricultural chemicals.
| | Reference | R. Garth Pews, J. A. Gall, Process and intermediates for the preparation of 2,6-difluoroaniline, Paten US5041674A
| | Chemical Properties | dark red liquid | | Uses | 2,4-Difluoroaniline is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields. | | General Description | Dark reddish-purple liquid. | | Air & Water Reactions | 2,4-Difluoroaniline may be sensitive to prolonged exposure to air. . Water soluble. | | Reactivity Profile | Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. | | Health Hazard | ACUTE/CHRONIC HAZARDS: 2,4-Difluoroaniline may be irritating to tissues. | | Fire Hazard | 2,4-Difluoroaniline is combustible. | | Synthesis | The general procedure for the synthesis of 2,4-difluoroaniline from 2,4-difluoronitrobenzene was as follows: 2,4-difluoro-1-nitrobenzene (1 g), methanol (10 mL), and Pd/C catalyst (100 mg) were added to a 100 mL single-necked reaction flask. Subsequently, the reaction system was replaced three times with hydrogen to remove air. The reaction mixture was stirred at room temperature for 2-3 hours. Upon completion of the reaction, the catalyst was removed by filtration under reduced pressure and the filtrate was concentrated to give 810 mg of the target product 2,4-difluoroaniline. | | References | [1] Synthetic Communications, 2012, vol. 42, # 2, p. 213 - 222
[2] Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry, 2011, vol. 41, # 1, p. 114 - 119
[3] Journal fuer Praktische Chemie (Leipzig), 1934, vol. <2> 140, p. 97,111
[4] Chemische Berichte, 1937, vol. 70, p. 2396,2400 |
| | 2,4-Difluoroaniline Preparation Products And Raw materials |
| Raw materials | Iron-->Potassium fluoride-->1,3-Dichlorobenzene-->m-Phenylenediamine-->2,4-Difluoronitrobenzene-->2-Chloro-3,4-difluoroaniline-->3-CHLORO-2,4-DIFLUOROANILINE 99-->Activated carbon-->Palladium-->Hydrogen | | Preparation Products | TOSUFLOXACIN TOSILATE-->TEMAFLOXACIN-->Diflufenican-->Diflunisal-->2,4,5-Trifluorobenzoic acid-->N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine-->2-Bromo-4,6-difluorophenol-->2,4-DIFLUORO-6-NITROANILINE-->2-AMINO-4,6-DIFLUOROBENZOTHIAZOLE-->Benzamide, 5-chloro-N-(2,4-difluorophenyl)-2-hydroxy--->1H-Pyrrole-3-carboxaldehyde, 1-(2,4-difluorophenyl)-2,5-dimethyl--->1-(2,4-DIFLUORO-PHENYL)-1H-PYRROLE-2-CARBALDEHYDE-->N-(2,4-DIFLUOROPHENYL)MALEAMIC ACID-->benzyl 2,4-difluoro-3-forMylphenylcarbaMate-->Acetamide, N-(2,4-difluorophenyl)-2-(hydroxyimino)- |
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