| Company Name: |
INTATRADE GmbH |
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- 3,5-Difluoroaniline
-
-
2026-06-30
- CAS:372-39-4
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10000KGS
- 3,5-Difluoroaniline
-
-
2025-06-27
- CAS:372-39-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500000kg
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| | 3,5-Difluoroaniline Basic information | | Synthesis |
| Product Name: | 3,5-Difluoroaniline | | Synonyms: | 3,5-Difluoroaniline 98%;3,5-DIFLUOROBENZENEAMINE;3,5-DIFLUOROBENZENAMINE;3,5-DIFLUOROANILINE;3,5-Difluoroaniline(AntibacterialAntiphlogistic,WeedKiller)(C6H5F2N);3,5-Difluoroaniline,98%;Benzenamine, 3,5-difluoro;3,5-Difluoronitroaniline | | CAS: | 372-39-4 | | MF: | C6H5F2N | | MW: | 129.11 | | EINECS: | 206-752-8 | | Product Categories: | Fluorobenzene;Anilines, Aromatic Amines and Nitro Compounds;Miscellaneous;Amines;C2 to C6;Nitrogen Compounds;Fluorobenzene Series;bc0001 | | Mol File: | 372-39-4.mol |  |
| | 3,5-Difluoroaniline Chemical Properties |
| Melting point | 37-41 °C (lit.) | | Boiling point | 80°C 20mm | | density | 1,295 g/cm3 | | refractive index | 1,512-1,514 | | Fp | 167 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | Water Solubility | Insoluble in water | | form | Low Melting Solid | | pka | 2.57±0.10(Predicted) | | color | White to yellow | | BRN | 2802286 | | InChI | InChI=1S/C6H5F2N/c7-4-1-5(8)3-6(9)2-4/h1-3H,9H2 | | InChIKey | KQOIBXZRCYFZSO-UHFFFAOYSA-N | | SMILES | C1(N)=CC(F)=CC(F)=C1 | | CAS DataBase Reference | 372-39-4(CAS DataBase Reference) | | EPA Substance Registry System | 3,5-Difluoroaniline (372-39-4) |
| Hazard Codes | Xn,Xi | | Risk Statements | 20/21/22-36/37/38 | | Safety Statements | 28-36/37/39-26-36 | | RIDADR | UN 1325 4.1/PG 2 | | WGK Germany | 3 | | F | 8-10-23 | | Hazard Note | Irritant | | TSCA | TSCA listed | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29214200 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral |
| | 3,5-Difluoroaniline Usage And Synthesis |
| Synthesis |
Work on halogenated benzenes has also demonstrated the versatility of this technique and a variety of fluoro-chloro and -bromo benzenes may be de-brominated and de-chlorinated. Two patents describe removal of chlorine from 2,6-dichloro-3,5- difluoronitrobenzene giving 3,5-difluoroaniline.
| | Chemical Properties | white to yellowish low melting solid | | Uses | 3,5-Difluoroaniline has been used in the preparation of 3,5-difluorodimethylaniline. | | Application | 3,5-Difluoroaniline is mainly used as a key intermediate in the synthesis of complex organic molecules such as pharmaceuticals (e.g., antibacterial drugs, anti-inflammatory drugs), pesticides (e.g., herbicides), and dyes. | | General Description | In vitro nephrotoxic effects of 3,5-difluoroaniline has been investigated in renal cortical slices obtained from the kidneys of untreated, male Fischer 344 rats. | | References | [1] Patent: CN108314624, 2018, A. Location in patent: Paragraph 0054; 0055; 0056; 0057 |
| | 3,5-Difluoroaniline Preparation Products And Raw materials |
| Raw materials | 1-Bromo-3,5-difluorobenzene-->N-benzyl-3,5-difluoroaniline-->Hydrogen-->Methanol-->Activated carbon-->Palladium-->Sulfuric acid | | Preparation Products | 2,4-dibromo-1,3,5-trifluorobenzene-->4-Amino-2,6-difluoro-benzaldehyde-->2,4,6-Trifluorochlorobenzene-->2-Amino-4,6-difluorobenzoic acid-->3,5-Difluoro-4-iodoaniline-->3,5-Difluorobenzenesulfonamide-->N-Methyl 3,5-difluoroaniline-->1,3,5-Trifluorobenzene-->N-(3,5-Difluorophenyl)-4-nitrobenzenesulfonaMide, 97%-->Benzenamine, 3,5-difluoro-N,N-dimethyl- (9CI)-->N-(3,5-Difluorophenyl)-4-fluorobenzaMide, 97%-->2-(3,5-Difluorophenoxy)acetic acid-->5,7-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester |
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