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| | 2-Methyl-[1,2,6]thiadiazinane 1,1-dioxide Basic information |
| Product Name: | 2-Methyl-[1,2,6]thiadiazinane 1,1-dioxide | | Synonyms: | 2-methyl-3,4,5,6-tetrahydro-1,2,6-thiadiazine-1,1-dioxide;2H-1,2,6-Thiadiazine, tetrahydro-2-methyl-, 1,1-dioxide;2-Methyl-[1,2,6]thiadiazinane 1,1-dioxide | | CAS: | 137830-77-4 | | MF: | C4H10N2O2S | | MW: | 150.2 | | EINECS: | | | Product Categories: | | | Mol File: | 137830-77-4.mol | ![2-Methyl-[1,2,6]thiadiazinane 1,1-dioxide Structure](CAS/GIF/137830-77-4.gif) |
| | 2-Methyl-[1,2,6]thiadiazinane 1,1-dioxide Chemical Properties |
| Boiling point | 241.6±23.0 °C(Predicted) | | density | 1.250±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 12.50±0.20(Predicted) | | Appearance | White to off-white Solid |
| | 2-Methyl-[1,2,6]thiadiazinane 1,1-dioxide Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 2-methyl-[1,2,6]thiadiazine 1,1-dioxide from 3-methylaminopropylamine was as follows: a mixture of N-methyl-1,3-propanediamine (2.06 g, 23.4 mmol) and sulfonamide (0.748 g, 7.78 mmol) was placed in a microwaveable reaction flask, sealed, and then filled with argon gas for protection. The reaction flask was stirred overnight at 50°C, and then warmed to 160°C to continue the reaction with stirring for 20 minutes. Upon completion of the reaction, the reaction mixture was concentrated and the residue was purified by column chromatography to afford 2-methyl-1,2,6-thiadiazine 1,1-dioxide (0.82 g, 70% yield). | | References | [1] Journal of Medicinal Chemistry, 1994, vol. 37, # 19, p. 3023 - 3032
[2] European Journal of Medicinal Chemistry, 2007, vol. 42, # 9, p. 1176 - 1183
[3] Patent: WO2015/108861, 2015, A1. Location in patent: Paragraph 00401
[4] Patent: US2015/225422, 2015, A1. Location in patent: Paragraph 0555-0556
[5] Patent: US2013/303524, 2013, A1. Location in patent: Paragraph 0405-0406 |
| | 2-Methyl-[1,2,6]thiadiazinane 1,1-dioxide Preparation Products And Raw materials |
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