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| | (4-Nitro-pyrazol-1-yl)-acetic acid Basic information |
| Product Name: | (4-Nitro-pyrazol-1-yl)-acetic acid | | Synonyms: | (4-nitro-1H-pyrazol-1-yl)acetic acid(SALTDATA: FREE);ART-CHEM-BB B000219;CHEMBRDG-BB 5913009;(4-NITRO-1H-PYRAZOL-1-YL)ACETIC ACID;AKOS B000219;AKOS PAO-0916;TIMTEC-BB SBB000166;2-(4-nitro-1-pyrazolyl)acetic acid | | CAS: | 6645-69-8 | | MF: | C5H5N3O4 | | MW: | 171.11 | | EINECS: | | | Product Categories: | | | Mol File: | 6645-69-8.mol |  |
| | (4-Nitro-pyrazol-1-yl)-acetic acid Chemical Properties |
| Boiling point | 416.4±25.0 °C(Predicted) | | density | 1.71±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 3.33±0.10(Predicted) | | Appearance | White to light yellow Solid |
| Hazard Codes | Xi | | HazardClass | IRRITANT |
| | (4-Nitro-pyrazol-1-yl)-acetic acid Usage And Synthesis |
| Uses | (4-Nitro-1H-pyrazol-1-yl)acetic Acid is used in pharmacological study of effects of C-nitropyrazoles and C-nitroazoles on ocular blood flow and retinal function recovery after ischemic insult. | | Synthesis | An aqueous solution (100 mL) of potassium hydroxide (32.7 g, 0.58 mol) was slowly added to an acetone solution (500 mL) of 4-nitro-1H-pyrazole (30 g, 0.27 mol) under stirring at room temperature. After 30 minutes of reaction, an acetone solution (100 mL) of 2-bromoacetic acid (38.7 g, 0.27 mol) was added dropwise. The reaction mixture was continued to be stirred overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was diluted with water and extracted three times with ethyl acetate, the organic phases were combined and concentrated under reduced pressure. Subsequently, the residue was further extracted with a solvent mixture of dichloromethane and methanol, and the organic phases were combined and concentrated again under reduced pressure to give the target product 2-(4-nitro-1H-pyrazol-1-yl)acetic acid (40 g, 88% yield). | | References | [1] Patent: WO2013/174895, 2013, A1. Location in patent: Page/Page column 70 |
| | (4-Nitro-pyrazol-1-yl)-acetic acid Preparation Products And Raw materials |
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