金精三羧酸
| 中文名称 | 金精三羧酸 |
|---|---|
| 中文同义词 | 金精三羧酸;金黄三羧羧;金黄三羧酸;金精三羧酸|ATA;AURINTRICARBOXYLIC ACID (ATA),APOPTOSIS抑制剂;金精三羧酸,10 MM DMSO 溶液;金精三羧酸[A1895];金精三羧酸[A1895] |
| 英文名称 | Aurintricarboxylic acid |
| 英文同义词 | Aurintricarboxylic Acid - CAS 4431-00-9 - Calbiochem;1,4-cyclohexadiene-1-carboxylicacid,3-(bis(3-carboxy-4-hydroxyphenyl)methylen;5-[(3-carboxy-4-hydroxyphenyl)(3-carboxy-4-oxo-2,5-cyclohexadien-benzoicaci;aluminonfreeacid;e)-6-oxo-;5,5'-((3-Carboxy-4-oxocyclohexa-2,5-dien-1-ylidene);TIMTEC-BB SBB005410;LABOTEST-BB LT00080677 |
| CAS号 | 4431-00-9 |
| 分子式 | C22H14O9 |
| 分子量 | 422.34 |
| EINECS号 | 224-628-1 |
| 相关类别 | 生化试剂-色素类;化学试剂;色素类;通用生化试剂-生物染色剂与化学指示剂;有机化工原料;Colours, Dyes, Indicators & Pigments |
| Mol文件 | 4431-00-9.mol |
| 结构式 |  |
金精三羧酸 性质
| 熔点 | 300 °C(lit.) |
|---|---|
| 沸点 | 458.99°C (rough estimate) |
| 密度 | 1.3860 (rough estimate) |
| 折射率 | 1.6230 (estimate) |
| 储存条件 | +15C to +30C |
| 溶解度 | 1 M NH4OH：10 mg/mL |
| 形态 | 粉末 |
| 酸度系数(pKa) | 2.20±0.20(Predicted) |
| 颜色 | 暗红色至棕色 |
| 水溶解性 | Insoluble in water. |
| BRN | 2228904 |
| 主要应用 | 诊断试剂生产 血液学 组织学 |
| InChI | 1S/C22H14O9/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31) |
| InChIKey | GIXWDMTZECRIJT-UHFFFAOYSA-N |
| SMILES | OC(=O)c1cc(ccc1O)C(\c2ccc(O)c(c2)C(O)=O)=C3\C=CC(=O)C(=C3)C(O)=O |
| CAS 数据库 | 4431-00-9(CAS DataBase Reference) |
| EPA化学物质信息 | Benzoic acid, 5-[(3-carboxy-4-hydroxyphenyl)(3-carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methyl]-2-hydroxy- (4431-00-9) |
|
Topoisomerase II
|
rP2X1R 8.6 nM (IC 50 ) |
rP2X3R 72.9 nM (IC 50 ) |
Apoptosis
|
miRNA 0.47 μM (IC 50 ) |
Aurintricarboxylic acid strongly inhibits rP2X1Rs and rP2X3Rs with IC
50
values of 8.6 nM and 72.9 nM, respectively, and more weakly inhibits P2X2/3Rs, P2X2Rs, P2X4Rs or P2X7Rs.
Aurintricarboxylic acid inhibition of ATP-induced currents is concentration dependent.
Aurintricarboxylic acid is a non-competitive antagonist of P2X3R.
Aurintricarboxylic acid can inhibit the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) and vaccinia virus.
Aurintricarboxylic acid protects MDCK cells from infection with influenza A strains PR8, NY or N.
Aurintricarboxylic acid inhibits replication of influenza A and B viruses.
Aurintricarboxylic acid inhibits neuraminidase activities of influenza A and B viruses.
Aurintricarboxylic acid inhibits TWEAK-Fn14-mediated NF-κB activation.
Aurintricarboxylic acid (10 μM;0.5-2 hours) suppresses TWEAK-Fn14-mediated NF-κB, Akt, and Src phosphorylation in GBM cells.
Aurintricarboxylic acid blocks TWEAK-stimulated Rac1 activation and TRAF2 recruitment to Fn14 cytoplasmic domain in glioma cells.
Aurintricarboxylic acid represses TWEAK-stimulated glioma cell migration and invasion without causing cell cytotoxicity.
Aurintricarboxylic acid (Compound 8) cannot regulate loading of endogenous let-7 onto AGO2 inside cultured cells, whereas can inhibit RISC loading of exogenous siRNA.
Western Blot Analysis
| Cell Line: | T98G, A172, GBM44 glioma cells |
| Concentration: | 10 μM |
| Incubation Time: | 0.5 hour, 1 hour, 2 hours |
| Result: | Abrogated TWEAK activation of downstream signals including phosphorylation of the NF-κB family member p65, Akt, and Src in all three GBM cell lines. |
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