Lin28-IN-1
| 中文名称 | Lin28-IN-1 |
|---|---|
| 中文同义词 | 4-(7-(4-((苯甲氧基)羰基)哌嗪-1-基)-4,4-二甲基-8-硝基苯并吡喃并[4,3-C]吡唑-1(4H)-基)苯甲酸;化合物LIN28-LET-7A ANTAGONIST 1;化合物LIN28-LET-7A ANTAGONIST 1,10 MM DMSO 溶液 |
| 英文名称 | Lin28-IN-1 |
| 英文同义词 | Lin28-IN-1;Lin28-let-7a antagonist 1;1-Piperazinecarboxylic acid, 4-[1-(4-carboxyphenyl)-1,4-dihydro-4,4-dimethyl-8-nitro[1]benzopyrano[4,3-c]pyrazol-7-yl]-, 1-(phenylmethyl) ester;4-(7-(4-((Benzyloxy)carbonyl)piperazin-1-yl)-4,4-dimethyl-8-nitrochromeno[4,3-c]pyrazol-1(4H)-yl)benzoic acid;Inhibitor,inhibit,MicroRNA,Lin-28-let-7a antagonist 1,Lin28 let 7a antagonist 1,miRNA,Lin28let7a antagonist 1;Lin28-let-7a antagonist 1, 10 mM in DMSO |
| CAS号 | 2024548-03-4 |
| 分子式 | C31H29N5O7 |
| 分子量 | 583.59 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2024548-03-4.mol |
| 结构式 |  |
Lin28-IN-1 性质
| 沸点 | 813.8±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.42±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 酸度系数(pKa) | 3.72±0.10(Predicted) |
| 颜色 | 浅黄至黄色 |
IC50：4.03 μM (Lin28A-let-7a-1).
Lin28-let-7a antagonist 1 (compound 1) shows a clear antagonistic effect against the Lin28A-let-7a-1 interaction with an IC 50 of 4.03 μM. Interestingly, Lin28-let-7a antagonist 1 also inhibits the Lin28B-let-7 interaction, with slightly reduced potency. Dicer processing assay reveals that Lin28-let-7a antagonist 1 clearly blocks the formation of the Lin28A-pre-let-7g complex and induces miRNA processing, resulting in the generation of mature let-7g miRNA. When the expression of both Lin28A and Lin28B are knocked-down using siRNA in JAR cells, the Lin28-let-7a antagonist 1-induced increase in cellular let-7 levels is clearly attenuated. Lin28A-let-7a-IN-1 increases mature let-7 levels in PA-1 cells that express high level of Lin28A. On the other hand, let-7 levels are not affected by 1 in MCF7 cells that rarely express Lin28 proteins. Taken together, Lin28-let-7a antagonist 1 specifically induces the increase in the cellular let-7 levels by targeting Lin28.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-100692 | Lin28-let-7a antagonist 1 | 2024548-03-4 | 1 mg | 1400元 |
| 2025/12/22 | HY-100692 | 4-(7-(4-((苯甲氧基)羰基)哌嗪-1-基)-4,4-二甲基-8-硝基苯并吡喃并[4,3-C]吡唑-1(4H)-基)苯甲酸 Lin28-let-7a antagonist 1 | 2024548-03-4 | 5mg | 2800元 |