PAR4 (1-6) (mouse) (trifluoroacetate salt)

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Company Name: Shanghai Hongye Biotechnology Co. Ltd  
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PAR4 (1-6) (mouse) (trifluoroacetate salt) Basic information
Product Name:PAR4 (1-6) (mouse) (trifluoroacetate salt)
Synonyms:PAR4 (1-6) (mouse) (trifluoroacetate salt)
CAS:
MF:
MW:0
EINECS:
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Mol File:Mol File
PAR4 (1-6) (mouse) (trifluoroacetate salt) Structure
PAR4 (1-6) (mouse) (trifluoroacetate salt) Chemical Properties
solubility Water: 1 mg/ml
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MSDS Information
PAR4 (1-6) (mouse) (trifluoroacetate salt) Usage And Synthesis
DescriptionPAR4 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 4 (PAR4; EC50 = 30 μM in Xenopus oocytes expressing human PAR4 receptors) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse PAR4 and residues 60-65 of the full-length sequence.1 It induces calcium release in wild-type and PAR3-/- mouse platelets and in human platelets but has no activity in Xenopus oocytes expressing human PAR1. PAR4 (1-6) also triggers [3H]inositol phosphate release from KOLF cells expressing human PAR4.2WARNING This product is not for human or veterinary use.
References[1] MARK L. KAHN. A dual thrombin receptor system for platelet activation[J]. Nature, 1998, 394 6694: 690-694. DOI: 10.1038/29325
[2] T R FARUQI. Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function.[J]. The Journal of Biological Chemistry, 2000, 275 26: 19728-19734. DOI: 10.1074/jbc.m909960199
PAR4 (1-6) (mouse) (trifluoroacetate salt) Preparation Products And Raw materials
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