| Company Name: |
Amatek Scientific Co. Ltd.
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| Tel: |
0512-56316828 400-867-5858;400-867-5858 |
| Email: |
info@amateksci.com |
| Products Intro: |
Product Name:FmocNH-PEG3-CH2COONHS
CAS:2128735-25-9
Purity:97% HPLC Package:1g;5g;25g;100g
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| | Fmoc-PEG3-CH2CO2-NHS Basic information |
| Product Name: | Fmoc-PEG3-CH2CO2-NHS | | Synonyms: | Fmoc-PEG3-CH2CO2-NHS;FmocNH-PEG3-CH2COONHS;Fmoc-N-PEG3-CH2-NHS ester;FmocNH-PEG3-CH2COONHS/5,8,11-Trioxa-2-azatridecanedioic acid, 13-(2,5-dioxo-1-pyrrolidinyl) 1-(9H-fluoren-9-ylmethyl) ester;5,8,11-Trioxa-2-azatridecanedioic acid, 13-(2,5-dioxo-1-pyrrolidinyl) 1-(9H-fluoren-9-ylmethyl) ester;Fmoc-N-Amido-PEG3-C2-NHS ester | | CAS: | 2128735-25-9 | | MF: | C27H30N2O9 | | MW: | 526.54 | | EINECS: | | | Product Categories: | | | Mol File: | 2128735-25-9.mol |  |
| | Fmoc-PEG3-CH2CO2-NHS Chemical Properties |
| density | 1.35±0.1 g/cm3(Predicted) | | solubility | Soluble in DMSO, DCM, DMF | | pka | 11.60±0.46(Predicted) |
| | Fmoc-PEG3-CH2CO2-NHS Usage And Synthesis |
| Description | Fmoc-PEG3-CH2CO2-NHS is a PEG linker containing an Fmoc group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. | | Uses | Fmoc-N-PEG3-CH2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Fmoc-PEG3-CH2CO2-NHS Preparation Products And Raw materials |
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