| Company Name: |
Atlas antibodies
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| Tel: |
46-854595850 |
| Email: |
order@atlasantibodies.com |
| Products Intro: |
Product Name:Anti-CD19
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Email: |
ordercn@merckgroup.com |
| Products Intro: |
Product Name:Anti-CD19 antibody produced in chicken
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| | ANTI-HUMAN CD19 Basic information |
| Product Name: | ANTI-HUMAN CD19 | | Synonyms: | ANTI-HUMAN CD19, CLONE B-C3, MONOCLONAL ANTIBODY;Anti-CD19 antibody produced in chicken;ANTI-CD19(B-CELLS), HUMAN;ANTI-CD19 B CELLS;ANTI-HUMAN B4;ANTI-B4;ANTI-CD19, PAN B-CELLS;ANTI-CD19 (HUMAN) | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-HUMAN CD19 Structure]() |
| | ANTI-HUMAN CD19 Chemical Properties |
| storage temp. | 2-8°C | | form | buffered aqueous solution | | biological source | chicken |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | WGK 1 | | Storage Class | 10 - Combustible liquids |
| | ANTI-HUMAN CD19 Usage And Synthesis |
| Uses | CD19 is a 95kDa protein localized on the surface of nearly all B lymphocytes, and is considered to be the specific surface marker for B cells. This protein belongs to the immunoglobulin (Ig) superfamily with a cytoplasmic region of ~240 amino acids, and is involved in the regulation of B cell function. The protein is encoded by the 7.41kb cd19 gene, mapped on the short arm of human chromosome 16p11.2.
There are certain localized regions of strong net negative charge with nine tyrosine residues in the cytoplasmic region of CD19. These regions might regulate the interaction of CD19 with the proto-oncogene Vav, phosphatidylinositol-3 kinase (PI-3 kinase), and the Lyn, Lck, and Fyn protein tyrosine kinases. | | Biological Activity | CD19 expression is restricted to normal and malignant B-lineage cells. Therefore, it is considered to be a striking target for immunotherapies aimed at B-cell malignancies. CD19 helps B lymphocytes to initiate primary immune response even at low concentrations of antigen. The encoded protein plays a crucial role in initiating intrinsic B cell signaling thresholds by regulating both B cell receptor (BCR)-dependent and independent signaling. It also functions as a biomarker for B-cell development. |
| | ANTI-HUMAN CD19 Preparation Products And Raw materials |
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