ZEN-3219 manufacturers
- ZEN-3219
-
- $30.00
-
2026-07-14
- CAS:1952264-34-4
- Purity: 99.86%
- Supply Ability: 10g
- ZEN-3219
-
- $30.00
-
2026-07-14
- CAS:1952264-34-4
- Purity: 99.86%
- Supply Ability: 10g
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| | ZEN-3219 Basic information |
| Product Name: | ZEN-3219 | | Synonyms: | ZEN-3219;2(1H)-Pyridinone, 5-(3,5-dimethyl-4-isoxazolyl)-1-[[4-(2-oxiranyl)phenyl]methyl]-;ZEN3219,ZEN 3219 | | CAS: | 1952264-34-4 | | MF: | C19H18N2O3 | | MW: | 322.36 | | EINECS: | | | Product Categories: | | | Mol File: | 1952264-34-4.mol |  |
| | ZEN-3219 Chemical Properties |
| Boiling point | 588.3±50.0 °C(Predicted) | | density | 1.296±0.06 g/cm3(Predicted) | | pka | -0.93±0.70(Predicted) | | form | Solid | | color | White to off-white |
| | ZEN-3219 Usage And Synthesis |
| Uses | ZEN-3219 is a BET inhibitor with IC50s of 0.48, 0.16 and 0.47 μM for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively. ZEN-3219 can be used to form PROTACs to induce degradation of BRD4[1]. | | IC 50 | BRD4 (BD1): 0.48 μM (IC50); BRD4 (BD2): 0.16 μM (IC50); BRD4(BD1BD2): 0.47 μM (IC50) | | References | [1] Kharenko OA, et al. Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine. J Med Chem. 2018 Sep 27;61(18):8202-8211. DOI:10.1021/acs.jmedchem.8b00666 |
| | ZEN-3219 Preparation Products And Raw materials |
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