VH032-C3-NH2 manufacturers
- (S,R,S)-AHPC-C3-NH2
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2025-06-07
- CAS:2361119-88-0
- Min. Order: 100mg
- Purity: >95.00%
- Supply Ability: 100mg
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| | VH032-C3-NH2 Basic information |
| Product Name: | VH032-C3-NH2 | | Synonyms: | VH032-C3-NH2;VH032-C3-NH2((S,R,S)-AHPC-C3-NH2);VH032-C2-NH2;(2S,4R)-1-[(2S)-2-(4-aminobutanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide | | CAS: | 2361119-88-0 | | MF: | C26H37N5O4S | | MW: | 515.67 | | EINECS: | | | Product Categories: | | | Mol File: | 2361119-88-0.mol |  |
| | VH032-C3-NH2 Chemical Properties |
| Boiling point | 819.5±65.0 °C(Predicted) | | density | 1.242±0.06 g/cm3(Predicted) | | pka | 14.08±0.40(Predicted) |
| | VH032-C3-NH2 Usage And Synthesis |
| Uses | (S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852 (HY-130708). UNC6852 is an EED-targeted bivalent chemical degrader[1]. | | IC 50 | VHL | | References | [1] Potjewyd F, et al. Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader. Cell Chem Biol. 2020 Jan 16;27(1):47-56.e15. DOI:10.1016/j.chembiol.2019.11.006 |
| | VH032-C3-NH2 Preparation Products And Raw materials |
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