- 1-Boc-3-aminopyrrolidine
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- $0.00 / 1KG
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2026-05-14
- CAS:186550-13-0
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 30tons/month
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| | tert-Butyl 3-aminopyrrolidine-1-carboxylate Basic information |
| | tert-Butyl 3-aminopyrrolidine-1-carboxylate Chemical Properties |
| Boiling point | 257.4±33.0 °C(Predicted) | | density | 1.022 | | Fp | 91°C | | refractive index | 1.4710 | | storage temp. | 2-8°C | | pka | 9.55±0.20(Predicted) | | form | powder to lump to clear liquid | | color | White or Colorless to Light yellow | | Sensitive | Air Sensitive | | InChI | 1S/C9H18N2O2/c1-9(2,3)13-8(12)11-5-4-7(10)6-11/h7H,4-6,10H2,1-3H3 | | InChIKey | CMIBWIAICVBURI-UHFFFAOYSA-N | | SMILES | CC(C)(C)OC(=O)N1CCC(N)C1 | | CAS DataBase Reference | 186550-13-0(CAS DataBase Reference) |
| Hazard Codes | C,Xi,Xn | | Risk Statements | 36/37/38-44-41-22 | | Safety Statements | 26-36/37/39 | | RIDADR | 2810 | | WGK Germany | 3 | | Hazard Note | Irritant | | HazardClass | 8 | | PackingGroup | Ⅲ | | HS Code | 29339900 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Eye Dam. 1 |
| | tert-Butyl 3-aminopyrrolidine-1-carboxylate Usage And Synthesis |
| Chemical Properties | Colorless low melting solid or liquid | | Uses | 1-Boc-3-Aminopyrrolidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | | Synthesis | Step (ii): preparation of tert-butyl 3-aminopyrrolidine-1-carboxylate (Formula 49)
To a stirred solution of tert-butyl 3-hydroxypyrrolidine-1-carboxylate (Formula 48, 1.15 g, 4.16 mmol) in methanol (16.6 mL) was added 10% palladium/carbon catalyst (345 mg). The reaction mixture was stirred for 16 hours under a hydrogen atmosphere (hydrogen pressure applied via a double-layer balloon). Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad to remove the catalyst and the filtrate was concentrated under reduced pressure. The crude product was purified by silica gel fast column chromatography to afford the target compound tert-butyl 3-aminopyrrolidine-1-carboxylate (Formula 49, 640 mg) in 82% yield.
1H-NMR (CDCl3): δ 3.65-3.45 (m, 3H), 3.45-3.33 (m, 1H), 3.20-3.0 (m, 1H), 2.12-2.02 (m, 1H), 1.80-1.65 (m, 1H), 1.46 (s, 9H).
Mass spectrum (m/z): 187 [M+H]+. | | References | [1] Patent: WO2005/77924, 2005, A1. Location in patent: Page/Page column 76
[2] Patent: WO2011/30349, 2011, A1. Location in patent: Page/Page column 36-37 |
| | tert-Butyl 3-aminopyrrolidine-1-carboxylate Preparation Products And Raw materials |
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