| Company Name: |
Aemon Chemical |
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0086-755-86198205 |
| Email: |
acinfo@aemonchem.com |
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| | Methyl 4-(4-pyridinyl)benzoate Basic information |
| Product Name: | Methyl 4-(4-pyridinyl)benzoate | | Synonyms: | Methyl 4-(pyridin-4-yl)benoate;METHYL 4-PYRIDIN-4-YL-BENZATE;AKOS BAR-0605;Benzoic acid, 4-(4-pyridinyl)-, methyl ester;METHYL 4-(PYRIDIN-4-YL)BENZOATE;Methyl 4-(4-pyridinyl)benzoate | | CAS: | 106047-17-0 | | MF: | C13H11NO2 | | MW: | 213.23 | | EINECS: | | | Product Categories: | | | Mol File: | 106047-17-0.mol |  |
| | Methyl 4-(4-pyridinyl)benzoate Chemical Properties |
| Melting point | 103-105℃ | | Boiling point | 160 °C(Press: 1 Torr) | | density | 1.147 | | storage temp. | Inert atmosphere,Room Temperature | | pka | 4.98±0.10(Predicted) |
| | Methyl 4-(4-pyridinyl)benzoate Usage And Synthesis |
| Synthesis | Step A: 4-Bromopyridine (3.0 g, 19.0 mmol), 4-methoxycarbonylphenylboronic acid (2.63 g, 14.6 mmol), Pd(PPh3)2Cl2 (0.35 g, 0.5 mmol) and sodium carbonate (6.91 g, 65.2 mmol) were dissolved in 1,2-dimethoxyethane (40 mL) under nitrogen protection. The reaction mixture was heated to 90 °C and stirred for 10 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 6:1 to 2:1) to afford methyl 4-(pyridin-4-yl)benzoate (2.7 g, yield: 86.8%) as a white solid. m/z MS (ESI): 214 [M+H]+. | | References | [1] Patent: EP3190113, 2017, A1. Location in patent: Paragraph 0101
[2] Patent: TWI558709, 2016, B. Location in patent: Page/Page column 50; 51
[3] Patent: US2004/242572, 2004, A1. Location in patent: Page/Page column 73 |
| | Methyl 4-(4-pyridinyl)benzoate Preparation Products And Raw materials |
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