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SNC 80 manufacturers
- SNC 80
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- $53.00
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2026-07-31
- CAS:156727-74-1
- Purity: 99.65%
- Supply Ability: 10g
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| Product Name: | SNC 80 | | Synonyms: | 4-[(R)-[(2S,5R)-2,5-Dimethyl-4-(2-propen-1-yl)-1-piperazinyl](3-methoxyphenyl)methyl]-N,N-diethylbenzamide;(+)-4-[(Ar)-alpha-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3;NIH 10815;(+)-4-[(AR)-A-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAM;(+)-4-[(AR)-A-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAMIDE;(+)-4-[(AR)-ALPHA-((2S,5R)-4-ALLYL-2,5-DIMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAMIDE;SNC 80;(+)-4-[(αr)-α-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-n,n-diethylbenzamide | | CAS: | 156727-74-1 | | MF: | C28H39N3O2 | | MW: | 449.63 | | EINECS: | | | Product Categories: | Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Chiral Reagents;Opioid receptor and opioid-like receptor | | Mol File: | 156727-74-1.mol |  |
| | SNC 80 Chemical Properties |
| Melting point | 122-123°C | | Boiling point | 564.8±50.0 °C(Predicted) | | density | 1.040 | | storage temp. | Store at RT | | solubility | DMSO: soluble | | form | solid | | pka | 7.29±0.10(Predicted) | | color | off-white | | Stability: | Store in Freezer | | InChIKey | KQWVAUSXZDRQPZ-UMTXDNHDSA-N | | SMILES | C(N(CC)CC)(=O)C1=CC=C([C@@H](N2C[C@@H](C)N(CC=C)C[C@@H]2C)C2=CC=CC(OC)=C2)C=C1 |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | SNC 80 Usage And Synthesis |
| Description | SNC 80 is a selective nonpeptide agonist of the δ-opioid receptor (Ki = 0.18 nM, IC50 = 2.73 nM) that is over 2,000-fold less effective at the μ-opioid receptor. It effectively activates μ/δ receptor heteromers (EC50 = 52.8 nM) but not κ/δ or μ/κ heteromers. SNC 80 has antinociceptive as well as pro-convulsant effects in vivo. | | Chemical Properties | Crystalline Solid | | Uses | A highly selective and potent non-peptide -agonist, 2000-fold selective over u-receptors | | Uses | Rats were administered SNC80 to study the role of nitric oxide synthase in peripheral antinociception mechanism.5 | | Definition | ChEBI: 4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enyl-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide is a diarylmethane. | | Biological Activity | A highly selective and potent non-peptide δ -opioid agonist, 2000-fold selective over μ -opioid receptors. | | Biochem/physiol Actions | SNC80 is a highly selective agonist of δ opioid receptor but also binds to μ-δ opioid receptor heteromers to produce antinociception in mice.2 It also acts as anti-depressant3, elicits dopamine-related behaviors and enhances behavioral responses to psychostimulants.4 | | storage | Store at RT | | References | [1] E J BILSKY. SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist.[J]. Journal of Pharmacology and Experimental Therapeutics, 1995, 273 1: 359-366.
[2] S. N. CALDERON. ChemInform Abstract: Probes for Narcotic Receptor Mediated Phenomena. Part 19. Synthesis of (+)-4-((αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)- 3-methoxybenzyl)-N,N-diethylbenzamide (SNC 80): A Highly Selective, Nonpeptide δ Opioid Receptor Agonist.[J]. ChemInform, 1994, 25 48. DOI: 10.1002/chin.199448177
[3] R J KNAPP. Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors.[J]. Journal of Pharmacology and Experimental Therapeutics, 1996, 277 3: 1284-1291.
[4] MATTHEW D. METCALF. The δ Opioid Receptor Agonist SNC80 Selectively Activates Heteromeric μ–δ Opioid Receptors[J]. ACS Chemical Neuroscience, 2012, 3 7: 505-509. DOI: 10.1021/cn3000394
[5] INGELA DANIELSSON . Electroencephalographic and convulsant effects of the delta opioid agonist SNC80 in rhesus monkeys[J]. Pharmacology Biochemistry and Behavior, 2006, 85 2: Pages 428-434. DOI: 10.1016/j.pbb.2006.09.012 |
| | SNC 80 Preparation Products And Raw materials |
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