PROTAMINE SULFATE manufacturers
- Protamine Sulfate
-
- $200.00
-
2021-11-15
- CAS:9009-65-8
- Min. Order: 100KG
- Purity: 98%
- Supply Ability: 50ton/Month
|
| | PROTAMINE SULFATE Basic information |
| Product Name: | PROTAMINE SULFATE | | Synonyms: | ProtamineSulphateExSalmonRoe;PROTAMINE SULFATE SALT;Protamine sulfate, Salmine sulfate from salmon sperm;Protamine sulfate 1g [9009-65-8];Ccris 8521;Protamina solfato;Protamina solfato [dcit];ProtaMine sulfates | | CAS: | 9009-65-8 | | MF: | H2O4S | | MW: | 0 | | EINECS: | 618-450-7 | | Product Categories: | | | Mol File: | Mol File | ![PROTAMINE SULFATE Structure]() |
| | PROTAMINE SULFATE Chemical Properties |
| storage temp. | -20°C | | solubility | H2O: 10 mg/mL | | form | amorphous powder | | color | white | | Water Solubility | It is sparingly soluble in water. | | Sensitive | Hygroscopic | | Cosmetics Ingredients Functions | SKIN CONDITIONING | | EPA Substance Registry System | Protamines, sulfates (9009-65-8) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | VO9470000 | | F | 21-10 | | TSCA | TSCA listed | | HS Code | 35040090 | | Storage Class | 11 - Combustible Solids |
| | PROTAMINE SULFATE Usage And Synthesis |
| Chemical Properties | White or almost white, hygroscopic powder. | | Uses | It is suitable for personal care, cosmetic and pharmaceutical applications. It is used widely to reverse the anticoagulant effects of heparin. It acts as a heparin antagonist. It is also a weak anticoagulant. It may be used for the removal of DNA from protein samples or the purification of DNA binding proteins. Protamine sulfate may also be used as an alternative to polybrene in retroviral mediated gene transfer. Protamine sulfate has antibacterial properties and inhibits pepsin activity. Protamine sulfate and other polycations have been shown to inhibit the classical pathway of complement. It neutralizes the anticoagulant activity of heparin, and inhibits turnover of lipoproteins by lipoprotein lipase. The aggregation of erythrocytes in the presence of protamine sulfate, for application to the prediction of MN phenotypes, has been investigated. | | Uses | Antidote (to heparin). | | in vivo | Protamine sulfate can be used in animal modeling to create cystitis models[5].
Induction of cystitis model[5] Background
The presence and activity of protamine sulfate may trigger the activation and inflammatory response of the host immune system. These immune responses can lead to the infiltration of inflammatory cells and the production of inflammatory mediators, such as cytokines and interleukins, which can lead to cystitis.
Specific Modeling Methods
Rat: Sprague-Dawley female &bull
Administration: 10 mg/mL irrigation in the urinary bladder once
Note
(1) 10 mg/ml protamine sulfate was injected into the rat bladder, and 2 mg/ml LPS was injected 30 minutes later
(2) 5 days later, the experimental animals were put to death under anesthesia, and the bladder was removed for observation.
Modeling Indicators Physiological indicators: The turbidity, urine volume and the number of red blood cells in the urine of rats were detected.
Molecular changes: The levels of biomarkers IL-6, TNF-α and NF-κB in bladder tissues were detected.
Histological analysis: Hematoxylin and eosin staining were used to detect the number of mast cells in the bladder of rats.
Correlated Product(s): LPS (HY-D1056) Opposite Product(s): / |
| | PROTAMINE SULFATE Preparation Products And Raw materials |
|