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| | 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid Basic information |
| Product Name: | 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid | | Synonyms: | SALOR-INT L252034-1EA;RARECHEM AL BO 0714;BUTTPARK 23\09-45;5-amino-1-(4-fluorophenyl)-4-pyrazolecarboxylic acid;5-Amino-4-carboxy-1-(4-fluorophenyl)-1H-pyrazole;5-Amino-4-carboxy-1-(4-fluorophenyl)-1H-pyrazole, 1-(5-Amino-4-carboxy-1H-pyrazol-1-yl)-4-fluorobenzene;5-Amino-1-(4-fluorophenyl)pyrazole-4-carboxylic Acid;1H-Pyrazole-4-carboxylic acid, 5-amino-1-(4-fluorophenyl)- | | CAS: | 187949-90-2 | | MF: | C10H8FN3O2 | | MW: | 221.19 | | EINECS: | | | Product Categories: | | | Mol File: | 187949-90-2.mol |  |
| | 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid Chemical Properties |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | Solid |
| | 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid Usage And Synthesis |
| Synthesis | mmol) in a solvent mixture of methanol (200 mL). The reaction mixture was heated to reflux for 17 h, followed by cooling to room temperature and filtration. The filtrate was acidified with 2 N HCl solution to pH=7. The precipitated solid was collected by filtration and dried under reduced pressure to afford the target compound 5-amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid as a light yellow solid (18.64 g, 95% yield), which was used in subsequent reactions without further purification. | | References | [1] Patent: WO2008/53136, 2008, A1. Location in patent: Page/Page column 36
[2] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 20, p. 5032 - 5038
[3] Journal of Medicinal Chemistry, 2006, vol. 49, # 5, p. 1562 - 1575
[4] Patent: WO2008/74814, 2008, A1. Location in patent: Page/Page column 56
[5] Patent: WO2008/777, 2008, A2. Location in patent: Page/Page column 58-59 |
| | 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid Preparation Products And Raw materials |
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