6-(Hydroxymethyl)imidazo[1,2-a]pyridine manufacturers
|
| | 6-(Hydroxymethyl)imidazo[1,2-a]pyridine Basic information |
| Product Name: | 6-(Hydroxymethyl)imidazo[1,2-a]pyridine | | Synonyms: | IMidazo(1,2-a)pyridine-6-ylMethanol;IMidazo[1,2-a]pyridine-6-Methanol;(H-iMidazo[1,2-a]pyridin-6-yl)Methanol;6-(Hydroxymethyl)imidazo[1,2-a]pyridine97%;IMIDAZO[1,2-A]PYRIDIN-6-YLMETHANOL;6-(Hydroxymethyl)imidazo[1,2-a]pyridine;6-(Hydroxymethyl)imidazo[1,2-a]pyridine 97%;Imidazo[1,2-a]pyridine-6-methanol (9CI, ACI) | | CAS: | 132213-07-1 | | MF: | C8H8N2O | | MW: | 148.16 | | EINECS: | | | Product Categories: | | | Mol File: | 132213-07-1.mol | ![6-(Hydroxymethyl)imidazo[1,2-a]pyridine Structure](CAS/GIF/132213-07-1.gif) |
| | 6-(Hydroxymethyl)imidazo[1,2-a]pyridine Chemical Properties |
| Melting point | 105-107 | | density | 1.26±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 13.36±0.10(Predicted) | | form | solid | | color | Beige |
| | 6-(Hydroxymethyl)imidazo[1,2-a]pyridine Usage And Synthesis |
| Definition | ChEBI: Imidazo[1,2-a]pyridin-6-ylmethanol is an imidazopyridine. | | Synthesis | To a solution of imidazo[1,2-a]pyridine-6-carboxylic acid (4.3 g, 27 mmol) in anhydrous tetrahydrofuran (25 mL) was added slowly and dropwise borane dimethyl sulfide complex (5.8 mL, 10 N, in dimethyl sulfide, 58 mmol) at 0 °C. The reaction mixture was stirred at 0 °C for 0.5 h, then warmed up to 80 °C and kept stirring for 3 h. The reaction mixture was then stirred for 0.5 h. The reaction mixture was cooled down to 0.5 °C. Upon completion of the reaction, the mixture was cooled to 0 °C, carefully quenched with methanol (10 mL) and subsequently concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with an eluent ratio of dichloromethane: methanol = 10:1 to afford imidazo[1,2-a]pyridine-6-methanol (1.0 g, 26% yield) as a white solid.LCMS analysis resulted in (ES+) m/z (M+H)+ = 149.1 and retention time tR = 0.279 min. | | References | [1] Patent: WO2015/66371, 2015, A1. Location in patent: Paragraph 00530-00531 |
| | 6-(Hydroxymethyl)imidazo[1,2-a]pyridine Preparation Products And Raw materials |
|