4-(Trifluoromethyl)phenacyl bromide

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4-(Trifluoromethyl)phenacyl bromide Basic information

Product Name:	4-(Trifluoromethyl)phenacyl bromide
Synonyms:	BUTTPARK 35\01-55;2-Bromo-4'-(trifluoromethyl)acetophenone, 2-Bromo-1-[4-(trifluoromethyl)phenyl]ethan-1-one;4'-(TRIFLUOROMETHYL)PHENACYL BROMIDE;4-TRIFLUOROMETHYLPHENACYL BROMIDE;2-BROMO-1-[4-(TRIFLUOROMETHYL)PHENYL]-1-ETHANONE;2-BROMO-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHAN-1-ONE;2-Bromo-1-[4-(trifluoromethyl)phenyl]ethan-1-one, tech;4-(Trifluoromethyl)phenacyl bromide 97%
CAS:	383-53-9
MF:	C9H6BrF3O
MW:	267.04
EINECS:	609-544-9
Product Categories:	Benzene series
Mol File:	383-53-9.mol

4-(Trifluoromethyl)phenacyl bromide Chemical Properties

Melting point	45 °C
Boiling point	264.2±40.0 °C(Predicted)
density	1.592±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	soluble in Methanol
form	powder to crystal
color	White to Yellow to Orange
InChI	1S/C9H6BrF3O/c10-5-8(14)6-1-3-7(4-2-6)9(11,12)13/h1-4H,5H2
InChIKey	HEMROKPXTCOASZ-UHFFFAOYSA-N
SMILES	FC(F)(F)c1ccc(cc1)C(=O)CBr
CAS DataBase Reference	383-53-9(CAS DataBase Reference)

Safety Information

MSDS Information

4-(Trifluoromethyl)phenacyl bromide Usage And Synthesis

Chemical Properties	White powder or crystal
Synthesis	313343-88-3 383-53-9 General procedure for the synthesis of 2-bromo-4'-(trifluoromethyl)acetophenone using 1-(bromoethynyl)-4-(trifluoromethyl)benzene as starting material: a mixed solution of haloalkynes (0.5 mmol), silver fluoride (5 mol%), and water (1 eq.) in trifluoroacetic acid (1 mL) was stirred for 6 hours at 40 °C. Upon completion of the reaction, the trifluoroacetic acid was recovered by distillation for reuse. The residue was purified by column chromatographic separation to afford the target product 2-bromo-4'-(trifluoromethyl)acetophenone.
References	[1] Tetrahedron Letters, 2014, vol. 55, # 7, p. 1373 - 1375 [2] European Journal of Organic Chemistry, 2016, vol. 2016, # 1, p. 116 - 121 [3] Tetrahedron, 2016, vol. 72, # 27-28, p. 3818 - 3822 [4] Tetrahedron Letters, 2016, vol. 57, # 45, p. 4983 - 4986 [5] Chinese Journal of Chemistry, 2016, vol. 34, # 12, p. 1251 - 1254

4-(Trifluoromethyl)phenacyl bromide Preparation Products And Raw materials

Raw materials	Diethyl ether-->Bromine-->1,4-Dioxane-->4'-(Trifluoromethyl)acetophenone-->1-(2-Bromoethynyl)-4-(trifluoromethyl)benzene-->4'-TRIFLUOROMETHYLPHENYL ACETYLENE-->Ethylene glycol-->4-(TRIFLUOROMETHYL)STYRENE
Preparation Products	1,3-Dioxolane, 2-(bromomethyl)-2-[4-(trifluoromethyl)phenyl]--->2-Oxazoleethanol, β,5-dibromo-4-[4-(trifluoromethyl)phenyl]-, 2-acetate-->1H-Isoindole-1,3(2H)-dione, 2-[2-oxo-2-[4-(trifluoromethyl)phenyl]ethyl]--->2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrimidine-->2-(Methylsulfanyl)-1-[4-(trifluoromethyl)phenyl]ethan-1-one

Tag:4-(Trifluoromethyl)phenacyl bromide(383-53-9) Related Product Information

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