Lenalidomide-PEG1-azide manufacturers
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| | Lenalidomide-PEG1-azide Basic information |
| Product Name: | Lenalidomide-PEG1-azide | | Synonyms: | Lenalidomide-PEG1-azide;Acetamide, 2-(2-azidoethoxy)-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-;2-(2-azidoethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)acetamide;2-(2-Azidoethoxy)-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]acetamide | | CAS: | 2185795-67-7 | | MF: | C17H18N6O5 | | MW: | 386.37 | | EINECS: | | | Product Categories: | | | Mol File: | 2185795-67-7.mol |  |
| | Lenalidomide-PEG1-azide Chemical Properties |
| solubility | DMSO : 100 mg/mL (258.83 mM; Need ultrasonic) | | form | Solid | | color | Off-white to light yellow |
| | Lenalidomide-PEG1-azide Usage And Synthesis |
| Uses | Lenalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Lenalidomide-PEG1-azide incorporates the Lenalidomide based cereblon ligand and a linker.Lenalidomide-PEG1-azidecan be used to design a PROTAC BRD4 Degrader-2 (HY-133136)[1]. Lenalidomide-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | Biological Activity | Lenalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Lenalidomide-PEG1-azide incorporates the Lenalidomide based cereblon ligand and a linker. Lenalidomide-PEG1-azide can be used to design a PROTAC BRD4 Degrader-2 [1]. | | References | [1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228. |
| | Lenalidomide-PEG1-azide Preparation Products And Raw materials |
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