Pomalidomide-NH-PEG3-azide manufacturers
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| | Pomalidomide-NH-PEG3-azide Basic information |
| Product Name: | Pomalidomide-NH-PEG3-azide | | Synonyms: | Pomalidomide-NH-PEG3-azide;IUN-36463;4-((2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;Pomalidomide 4'-PEG3-azide;1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-;4-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;4-[[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | | CAS: | 2271036-46-3 | | MF: | C21H26N6O7 | | MW: | 474.47 | | EINECS: | | | Product Categories: | | | Mol File: | 2271036-46-3.mol |  |
| | Pomalidomide-NH-PEG3-azide Chemical Properties |
| form | Solid | | color | Light yellow to yellow |
| | Pomalidomide-NH-PEG3-azide Usage And Synthesis |
| Uses | Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4'-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1degrader based on Rucaparib by using the PROTAC approach[1]. Pomalidomide 4'-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | Cereblon | | storage | Store at -20°C | | References | [1] Shuai Wang, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec;15(12):1223-1231. DOI:10.1038/s41589-019-0379-2 |
| | Pomalidomide-NH-PEG3-azide Preparation Products And Raw materials |
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